| Accession |
PRJCA003927 |
| Title |
An atlas of infiltrated B-lymphocytes in breast cancer revealed by paired single-cell RNA-sequencing and antigen receptor profiling |
| Relevance |
Medical |
| Data types |
Exome
Transcriptome or Gene expression
|
| Organisms |
Homo sapiens
|
| Description |
While it has been well recognized that T cell-mediated adaptive cellular immunity plays important roles in the cancer immune response and in tumor control, the roles of B lymphocytes in tumor development and therapy have only been proposed recently and are still mostly controversial. To gain mechanistic insights into the functions and developmental dynamics of tumor-infiltrated immune cells, especially B (TIL-B) lymphocytes, we combined single-cell RNA-sequencing (RNA-seq) and antigen receptor lineage analysis to characterize a large number of triple-negative breast cancer (TNBC)-infiltrated immune cells and presented a comprehensive atlas of infiltrated B lymphocytes in TNBC, the most aggressive breast cancer subtype. |
| Sample scope |
Single cell |
| Release date |
2021-01-11 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 33846305
|
Atlas of breast cancer infiltrated B-lymphocytes revealed by paired single-cell RNA-sequencing and antigen receptor profiling
|
Nature Communications
|
10.1038/s41467-021-22300-2
|
2021
|
|
|
| Data provider |
|
| Biomaterial provider |
Xinxiang central hospital, Xinxiang, Henan |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
General Program
|
81572795
|
|
| National Natural Science Foundation of China (NSFC)
|
General Program
|
81773304
|
|
| National Natural Science Foundation of China (NSFC)
|
Young Scientists Fund
|
31701135
|
|
| Beijing municipal government
|
Hundred, Thousand and Ten Thousand Talent Project
|
2019A39
|
|
| Health Commission of Henan Province
|
2018 Joint Construction Project of Henan Medical Science and Technology Tackling Plan
|
NO
|
|
|
|
| Submitter |
Yu
Zhang (zhangyu@nibs.ac.cn)
|
| Organization |
National Institute of Biological Sciences, Beijing |
| Submission date |
2020-11-25 |
