| Accession |
PRJCA003955 |
| Title |
Association between NR3C1 mutations and glucocorticoid resistance in children with acute lymphoblastic leukemia |
| Relevance |
Medical |
| Data types |
Genome sequencing
|
| Organisms |
Homo sapiens
|
| Description |
The outcome of patients with relapsed/refractory ALL remains unsatisfactory, despite these patients generally receive more intense therapy. Glucocorticoid (GC) resistance is a leading cause of treatment failure and relapse in ALL. Abnormal NR3C1 transcription and/or translation are strongly associated with GC resistance, but the underlying molecular mechanism and the clinical value of NR3C1 alterations with GC resistance in ALL treatment remain unclear. |
| Sample scope |
leukemic sample |
| Release date |
2021-02-28 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 35211470
|
Effects of NRAS Mutations on Leukemogenesis and Targeting of Children With Acute Lymphoblastic Leukemia
|
Frontiers in Cell and Developmental Biology
|
10.3389/fcell.2022.712484
|
2022
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Guangzhou Women and Children's Medical Center
|
|
IP-2018-001
|
|
| National Natural Science Foundation of China (NSFC)
|
|
81800122
|
|
| National Natural Science Foundation of China (NSFC)
|
|
32000392
|
|
|
|
| Submitter |
HUI
ZHANG (zhanghuirjh@gwcmc.org)
|
| Organization |
Guangzhou women and children's medical center |
| Submission date |
2020-11-30 |
