| 项目编号 |
PRJCA003955 |
| 项目标题 |
Association between NR3C1 mutations and glucocorticoid resistance in children with acute lymphoblastic leukemia |
| 涉及领域 |
Medical |
| 数据类型 |
Genome sequencing
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
The outcome of patients with relapsed/refractory ALL remains unsatisfactory, despite these patients generally receive more intense therapy. Glucocorticoid (GC) resistance is a leading cause of treatment failure and relapse in ALL. Abnormal NR3C1 transcription and/or translation are strongly associated with GC resistance, but the underlying molecular mechanism and the clinical value of NR3C1 alterations with GC resistance in ALL treatment remain unclear. |
| 样品范围 |
leukemic sample |
| 发布日期 |
2021-02-28 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 35211470
|
Effects of NRAS Mutations on Leukemogenesis and Targeting of Children With Acute Lymphoblastic Leukemia
|
Frontiers in Cell and Developmental Biology
|
10.3389/fcell.2022.712484
|
2022
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Guangzhou Women and Children's Medical Center
|
|
IP-2018-001
|
|
| National Natural Science Foundation of China (NSFC)
|
|
81800122
|
|
| National Natural Science Foundation of China (NSFC)
|
|
32000392
|
|
|
|
| 提交者 |
HUI
ZHANG (zhanghuirjh@gwcmc.org)
|
| 提交单位 |
Guangzhou women and children's medical center |
| 提交日期 |
2020-11-30 |
