| Accession |
PRJCA003974 |
| Title |
CHD8 mutant monkey |
| Relevance |
Model organism |
| Data types |
Whole genome sequencing
Transcriptome or Gene expression
|
| Organisms |
Macaca fascicularis
|
| Description |
Using CRISPR-Cas9 to disrupt the CHD8 gene in the embryos of cynomolgus monkeys, we found that CHD8 mutations selectively increased gliogenesis rather than neurogenesis to cause macrocephaly and autism-like behaviors in monkeys. Our findings support the idea that gliogenesis is critical for brain size in the primates and suggest that abnormal gliogenesis may result in ASD. |
| Sample scope |
Monoisolate |
| Release date |
2021-02-22 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 36878905
|
CHD8 mutations increase gliogenesis to enlarge brain size in the nonhuman primate
|
Cell Discovery
|
10.1038/s41421-023-00525-3
|
2023
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Chinese Academy of Sciences (CAS)
|
|
N/A
|
|
|
|
| Submitter |
Zhao
Hui (zhaohui@genetics.ac.cn)
|
| Organization |
Institute of Genetics and Developmental Biology, Chinese Academy of Sciences |
| Submission date |
2020-12-03 |
