Accession PRJCA003992
Title Profiling of human small bowel adenocarcinoma using single-cell RNA-seq
Relevance Medical
Data types Exome
Transcriptome or Gene expression
Organisms Homo sapiens
Description Small bowel adenocarcinoma is a type of rare malignant gastrointestinal tumors with a poor prognosis. To reveal molecular characteristics of malignant cells and microenvironment features of small bowel adenocarcinoma, we performed single-cell RNA-seq to analyze 48238 cells from tumor and adjacent normal tissues from 12 patients, which contain 6 duodenal cancer patients, 4 jejunal cancer patients and 2 ileal cancer patients. For 6 of these patients, we also adopted bulk whole exome sequencing to identity somatic mutations which may promote tumor progression and invasion.
Sample scope Single cell
Release date 2022-11-28
Publication
PubMed ID Article title Journal name DOI Year
36104333 Single-cell profiling reveals molecular basis of malignant phenotypes and tumor microenvironments in small bowel adenocarcinomas Cell Discovery 10.1038/s41421-022-00434-x 2022
Grants
Agency program Grant ID Grant title
ICG N/A
Submitter Fuchou    Tang  (tangfuchou@pku.edu.cn)
Organization Peking University
Submission date 2020-12-07

Project Data

Resource name Description
BioSample (38)  show -