| 项目编号 |
PRJCA003992 |
| 项目标题 |
Profiling of human small bowel adenocarcinoma using single-cell RNA-seq |
| 涉及领域 |
Medical |
| 数据类型 |
Exome
Transcriptome or Gene expression
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Small bowel adenocarcinoma is a type of rare malignant gastrointestinal tumors with a poor prognosis. To reveal molecular characteristics of malignant cells and microenvironment features of small bowel adenocarcinoma, we performed single-cell RNA-seq to analyze 48238 cells from tumor and adjacent normal tissues from 12 patients, which contain 6 duodenal cancer patients, 4 jejunal cancer patients and 2 ileal cancer patients. For 6 of these patients, we also adopted bulk whole exome sequencing to identity somatic mutations which may promote tumor progression and invasion. |
| 样品范围 |
Single cell |
| 发布日期 |
2022-11-28 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 36104333
|
Single-cell profiling reveals molecular basis of malignant phenotypes and tumor microenvironments in small bowel adenocarcinomas
|
Cell Discovery
|
10.1038/s41421-022-00434-x
|
2022
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| ICG
|
|
N/A
|
|
|
|
| 提交者 |
Fuchou
Tang (tangfuchou@pku.edu.cn)
|
| 提交单位 |
Peking University |
| 提交日期 |
2020-12-07 |
