| Accession |
PRJCA004007 |
| Title |
Construction of artificial multicellular system for transformation and utilization of inferior biomass |
| Relevance |
Biology |
| Data types |
Raw sequence reads
|
| Organisms |
fungi
Bacteria
|
| Description |
Aiming at the key metabolic enzymes and key intermediate metabolites such as glucose, xylose and acetic acid in the process of conversion and utilization of inferior biomass, fluorescent probe molecules were designed to realize high sensitivity detection of target enzyme activity and target metabolite molecules. Combined with droplet microfluidic technology, online detection of multi-cell system and highly adaptive evolution method were established. Based on the cognition of information response and cooperation, the advantages of this method were as follows By using promoter engineering and artificial transcription switch technology, a dynamic regulation method of metabolic function cooperation and adaptation is established to optimize the core metabolic function modules of degradation of inferior biomass and synthesis of useful chemicals in multicellular system, so as to maximize the material flow and energy flow of target products, reconstruct and strengthen the cofactor cycle, electron transfer chain and stress resistance Functional modules to improve the robustness and stability of metabolic performance of multi-cell system. |
| Sample scope |
Multispecies |
| Release date |
2020-12-08 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 34061258
|
Effect of liquid volume and microflora source on degradation rate and microbial community in corn stover degradation
|
AMB Express
|
10.1186/s13568-021-01233-5
|
2021
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
|
2018YFA0902200
|
|
|
|
| Submitter |
dan
zhu (zhud@tib.cas.cn)
|
| Organization |
Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences |
| Submission date |
2020-12-08 |
