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Accession PRJCA004164
Title Single cell analysis of hepatic alveolar echinococcosis lesion microenvironment reveals immunosuppressive and lesion metastasis-facilitating statuses
Relevance Medical
Data types Transcriptome or Gene expression
Organisms Homo sapiens
Description Human alveolar echinococcosis (AE), caused by infection with the small cyclophyllid tapeworm Echinococcus multilocularis, is a malignant-tumor-like infiltrating chronic disease, which majorly locates in the liver and has the potential to invade neighboring tissues or metastasize to distant organs. However, immune cell infiltration and their functional status in AE lesion microenvironment (LME) still remain unknown. Here, combining single-cell RNA sequencing (scRNA-seq) and single-cell T cell receptor (TCR) sequencing technologies. This work has revealed an initial immune landscape of AE-LME at single-cell level, and provided a conceptualized framework for the discovery of rational therapeutic targets in hepatic AE.
Sample scope Single cell
Release date 2021-01-12
Grants
Agency program Grant ID Grant title
National Natural Science Foundation of China (NSFC) Joint Funds of the National Natural Science Foundation of China U1303222 Research on the mechanisms of immune infiltration by Echinococcus
National Natural Science Foundation of China Regional Science Foundation Project of the National Natural Science Foundation of China 81960377 Study on the role of NKG2A-mediated functional exhaustion of NK cells in the pathogenesis of alveolar echinococcosis
National Natural Science Foundation of China Regional Science Foundation Project of the National Natural Science Foundation of China 81560098 Research on the mechanism of hepatic alveolar echinococcosis liver natural killer cells immune tolerance mediated by transforming growth factor-beta1
State Administration of Foreign Experts Affairs and Ministry of Education of the People The project of introducing talents to new disciplines in local colleges and Universities (111 Project) D17010 Talent introduction to the basis of Integrative System of Prevention, Diagnosis and Management for echinococcosis
State Key Laboratory of Pathogenesis, Prevention and Management of High Incidence Diseases in Central Asia Special Pogram on Echinococcosis SKL-HIDCA-BC6 Single-cell transcriptomic analysis of infiltrative immune cells in lesion microenvironment of echinococcosis
State Key Laboratory of Pathogenesis, Prevention and Management of High Incidence Diseases in Central Asia Youth Program SKL-HIDCA-2019-23 Study on the changes of peri-lesion CD45+ immune cells in hepatic alveolar echinococcosis based on single-cell transcriptome sequencing
Science and technology Department of Xinjiang Uyghur Autonomous Region Xinjiang Uyghur Autonomous Region Key Laboratory Open Research Program 2019D04021 Immunological characters of hepatic echinococcosis revealed by single-cell sequencing
Submitter Hao    Wen  (dr.wenhao@163.com)
Organization Xinjiang Medical University
Submission date 2020-12-31

Project Data

Resource name Description
BioSample (22)  show -