| Accession |
PRJCA004238 |
| Title |
Analysis of multicellular immune dynamics reveals pathogenic pathways and therapeutic targets for autoimmune uveitis |
| Relevance |
Medical |
| Data types |
single cell sequencing
|
| Organisms |
Mus musculus
Homo sapiens
|
| Description |
Cellular immunity is critical for central nervous system autoimmune diseases, such as uveitis, but individual cellular dynamics and pathologic mechanisms in evolving autoimmune responses remain poorly understood. By performing single-cell RNA sequencing, our findings provide insight into the molecular basis of EAU. |
| Sample scope |
Single cell |
| Release date |
2022-08-11 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 36195600
|
Multicellular immune dynamics implicate PIM1 as a potential therapeutic target for uveitis
|
Nature Communications
|
10.1038/s41467-022-33502-7
|
2022
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
National Key Technologies R&D Program
|
2017YFA0105804
|
|
|
|
| Submitter |
Wenru
Su (suwr3@mail.sysu.edu.cn)
|
| Organization |
Zhongshan Ophthalmic Center,Sun Yat-sen University |
| Submission date |
2021-01-11 |
