| 项目编号 |
PRJCA004238 |
| 项目标题 |
Analysis of multicellular immune dynamics reveals pathogenic pathways and therapeutic targets for autoimmune uveitis |
| 涉及领域 |
Medical |
| 数据类型 |
single cell sequencing
|
| 物种名称 |
Mus musculus
Homo sapiens
|
| 描述信息 |
Cellular immunity is critical for central nervous system autoimmune diseases, such as uveitis, but individual cellular dynamics and pathologic mechanisms in evolving autoimmune responses remain poorly understood. By performing single-cell RNA sequencing, our findings provide insight into the molecular basis of EAU. |
| 样品范围 |
Single cell |
| 发布日期 |
2022-08-11 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 36195600
|
Multicellular immune dynamics implicate PIM1 as a potential therapeutic target for uveitis
|
Nature Communications
|
10.1038/s41467-022-33502-7
|
2022
|
| 37132178
|
Sleep loss potentiates Th17‐cell pathogenicity and promotes autoimmune uveitis
|
Clinical and Translational Medicine
|
10.1002/ctm2.1250
|
2023
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
National Key Technologies R&D Program
|
2017YFA0105804
|
|
|
|
| 提交者 |
Wenru
Su (suwr3@mail.sysu.edu.cn)
|
| 提交单位 |
Zhongshan Ophthalmic Center,Sun Yat-sen University |
| 提交日期 |
2021-01-11 |
