| Accession |
PRJCA004258 |
| Title |
Integrative Single-Cell Epigenomic Landscape of Precision Immune Profiling Shows Memory Formation and Trained Immunity in COVID- 19 convalescent individuals |
| Relevance |
Medical |
| Data types |
Epigenomics
Raw sequence reads
|
| Organisms |
Homo sapiens
|
| Description |
Currently, the epigenomic regulation of immune responses to primary SARS-CoV-2 infection remains unknown. Here, we applied assay of single-cell transposase-accessible chromatin with sequencing (scATAC-seq) to analyze chromatin remodeling in the peripheral immune cells of 8 matched and uninfected healthy donors and 10 convalescent COVID-19 individuals who were recovered for 4-12 weeks from moderate or severe COVID-19 (referred to as COV-M and COV-S). This approach of 10x-based scATAC-seq enables the production of high-quality single-cell accessible chromatin profiles at massive scale across all major immune cell types in PBMCs |
| Sample scope |
Single cell |
| Release date |
2021-07-16 |
| Biomaterial provider |
the Fifth Medical Center of PLA General Hospital |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Chinese Academy of Sciences (CAS)
|
Strategic Priority Research Program of Chinese Academy of Sciences (CAS)
|
XDB37000000
|
|
|
|
| Submitter |
Pengyuan
Yang (pyyang@ibp.ac.cn)
|
| Organization |
Institute of Biophysics, Chinese Academy of Sciences |
| Submission date |
2021-01-13 |
