| Description |
Recent proteomic studies have shown that the human brain has about 14,000 gene expression products, and the dog brain is expected to have a similar amount of protein to the human brain. The protein expression spectrum of the dog brain and the specific expression spectrum of each functional area have not been parsed, which seriously hinders the study of brain development and neuro-related diseases using dogs as model organisms. The purpose of this project is to analyze the transcription almost a cell and protein expression and modification maps of the dog brain, and to provide an important information resource for research on brain development and neurobiology. Using the TMT (Tandem Mass Tag) marker quantitative proteomics method, a comprehensive database of family canines brain proteins was established by conducting comprehensive and in-depth research and comparing protein expression in six brain regions in three age groups, as well as comparing the differences between protein expression types and their abundance in different brain regions. In addition, we will screen the different brain regions of different brain regions of the dog to express proteins, to reveal the different physiological functions of each brain region and the family dog brain's social and emotional and cognitive function of the regulatory mechanism of the study provides a molecular basis. |
