Accession PRJCA004303
Title Single-cell transcriptomes of peripheral blood cells indicate and elucidate severity of COVID-19
Relevance Medical
Data types Transcriptome or Gene expression
Raw sequence reads
Organisms Homo sapiens
Description Here, we profiled the single-cell transcriptomes of 96,313 peripheral blood mononuclear cells (PBMCs) derived from 12 COVID-19 patients (including four moderate, four severe and four critical cases) and 3 healthy donors. Our work uncovers the cellular and molecular players underlying the disordered and heterogeneous immune responses associated with COVID-19 severity, which could provide valuable insights for the treatment of critical COVID-19 patients.
Sample scope Single cell
Release date 2021-01-20
Publication
PubMed ID Article title Journal name DOI Year
Single-cell transcriptomes of peripheral blood cells indicate and elucidate severity of COVID-19 SCIENCE CHINA Life Sciences doi.org/10.1007/s11427-020-1880-y
Grants
Agency program Grant ID Grant title
Ministry of Science and Technology of the People's Republic of China (MOST) 2018YFA0107801
Ministry of Science and Technology of the People's Republic of China (MOST) 2016YFA0100600
Ministry of Science and Technology of the People's Republic of China (MOST) 2017YFA0103400
National Natural Science Foundation of China (NSFC) 81421002
National Natural Science Foundation of China (NSFC) 81730006
National Natural Science Foundation of China (NSFC) 81890990
National Natural Science Foundation of China (NSFC) 81870086
National Natural Science Foundation of China (NSFC) 81670106
National Natural Science Foundation of China (NSFC) 81922002
CAMS Initiative for Innovative Medicine 2017-I2M-1-015
CAMS Initiative for Innovative Medicine 2019-I2M-1-006
CAMS Initiative for Innovative Medicine 2017-I2M-3-009
Submitter Tao    Cheng  (chengtao@ihcams.ac.cn)
Organization Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences
Submission date 2021-01-20

Project Data

Resource name Description
BioSample (12)  show -