| Accession | PRJCA004495 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Title | Mouse Single Islet β Cell Transcriptomics Reveal Sexually Dimorphic Transcriptomes and Type 2 Diabetes Genes | ||||||||||
| Relevance | Model organism | ||||||||||
| Data types |
Transcriptome or Gene expression
Raw sequence reads |
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| Organisms | Mus musculus | ||||||||||
| Description | Amounting evidence has shown that sex plays a crucial role for glucose homeostasis and onset risk of diabetes. Based on pancreatic β cell transcriptome profiling at single cell resolution, we focused on identifying sexually dimorphic transcriptomes and sex-dependent type 2 diabetes genes. Given the importance revealed by our study that different pathological mechanisms of type 2 diabetes exist between sexes, sex differences should be taken into consideration for innovative precision medicine when treating diabetes. | ||||||||||
| Sample scope | Single cell | ||||||||||
| Release date | 2021-07-02 | ||||||||||
| Publication |
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| Grants |
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| Submitter | Yana Li (liyana@picb.ac.cn) | ||||||||||
| Organization | Shanghai Institute of Nutrition and Health, CAS | ||||||||||
| Submission date | 2021-02-17 |