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Accession PRJCA004501
Title Multi-omics integrative analysis of esophageal squamous carcinoma
Relevance Medical
Data types Whole genome sequencing
Epigenomics
Transcriptome or Gene expression
Organisms Homo sapiens
Description In this study, we performed WGS, WGBS, RNA sequencing, and small RNA sequencing on tumor tissues as well as matched adjacent non-neoplastic tissues from ESCC patients to discover potential molecular subgroups. We present a comprehensive molecular profiling of ESCC with a focus on identifying novel molecular subgroups and functionally altered signaling pathways that may drive tumorigenesis and serve as prognostic or therapeutic signatures.
Sample scope Monoisolate
Release date 2022-11-30
Publication
PubMed ID Article title Journal name DOI Year
36272974 Characterization of somatic structural variations in 528 Chinese individuals with Esophageal squamous cell carcinoma Nature Communications 10.1038/s41467-022-33994-3 2022
37365153 The transcriptional landscape and diagnostic potential of long non-coding RNAs in esophageal squamous cell carcinoma Nature Communications 10.1038/s41467-023-39530-1 2023
38697989 Multimodal analysis of cfDNA methylomes for early detecting esophageal squamous cell carcinoma and precancerous lesions Nature Communications 10.1038/s41467-024-47886-1 2024
Grants
Agency program Grant ID Grant title
Ministry of Science and Technology of the People's Republic of China (MOST) National Key Technologies R&D Program 2016YFC1302100
Chinese Academy of Sciences (CAS) 2016I2M1001
Chinese Academy of Sciences (CAS) 2019I2M1003
Chinese Academy of Sciences (CAS) 2019I2M2004
National Natural Science Foundation of China (NSFC) 82030089
National Natural Science Foundation of China (NSFC) 81988101
National Natural Science Foundation of China (NSFC) 81972613
National Natural Science Foundation of China (NSFC) 81830086
National Natural Science Foundation of China (NSFC) 81903025
Shenzhen Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Sanming Project of Medicine in Shenzhen SZSM201812062
Department of science and technology of Guangdong Province the Guangdong Basic and Applied Basic Research Foundation 2019B030302012
Shenzhen Bay Laboratory Major Program of Shenzhen Bay Laboratory S201101004
the Science and Technology Innovation Committee of Shenzhen Municipality Shenzhen Key Project of Science and Technology JCYJ20200109120425045
Shanxi Education Department Shanxi 1331 Project Key Subjects Construction XK201708
Submitter Zhihua Liu (liuzh@cicams.ac.cn)
Organization National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Submission date 2021-02-17

Project Data

Resource name Description
BioSample (619)  show -