Accession PRJCA004588
Title Comparative analysis on infectious features between HSV-2 RL1 mutant strain and its wild-type strain HG52
Relevance Medical
Data types Raw sequence reads
Organisms Mus musculus
Description Human herpes simplex virus 2 (HSV-2), a double-stranded DNA virus with a complicated genomic structure and transcriptional mechanism, is the critical agent of genital herpes. This virus is frequently spread in young and adult populations via sexual contact, and infection in newborns can lead to neonatal encephalitis with a high fatality rate. This virus, which undergoes latent infection and reactivation in the sacral ganglia after the induction of genital or oral herpes, is a concern worldwide due to its severe negative effects on quality of life. Therefore, research on preventive measures for this disease has become an important topic. In this process, the ICP34.5 protein, which is encoded by the viral RL1 gene and has different structural forms, might impact cellular stress-induced translational arrest during viral infection and is involved in viral latent infectivity in neurons, probably via its effect on the alternative splicing of latent genes. In this study, BALB/c mice with HSV-2 sensitivity were used to investigate the pathologic characteristics of mice infected with HSV-2 RL1 mutant strain and HG52.
Sample scope Multiisolate
Release date 2021-03-05
Grants
Agency program Grant ID Grant title
National Natural Science Foundation of China (NSFC) 31670173
National Natural Science Foundation of China (NSFC) 81802868
Submitter Li    Qi-Han  (cherryzhang629@126.com)
Organization Institute of Medical Biology, Chinese Academy of Medicine Science and Peking Union Medical College
Submission date 2021-03-02

Project Data

Resource name Description
BioSample (21)  show -
GSA (1) -
CRA003994 Comparative analysis on infectious features between HSV-2 RL1 mutant strain and its wild-type strain HG52