Accession PRJCA004671
Title Inherited DNA methylation primes the establishment of accessible chromatin during genome activation
Relevance Model organism
Data types Epigenomics
Raw sequence reads
Organisms Danio rerio
Description For animals, epigenetic modifications can be globally or partially inherited from gametes after fertilization, but the mechanism underlying how the inherited epigenetic signatures affect transcriptional regulation during zygotic genome activation (ZGA) remains poorly understood. Here, we performed genome-wide profiling of chromatin accessibility during zebrafish ZGA, which is closely related to zygotic transcriptional regulation. The locations of the accessible chromatin at promoters were precisely primed by the enrichment of unmethylated CpGs that were fully inherited from gametes. On the other hand, distal regions with high methylation levels that were inherited from the sperm facilitated the binding of DNA methylation-preferred transcription factors, such as pou5f3 and nanog, which contributed to the establishment of accessible chromatin at these loci. Our results demonstrate a model whereby inherited DNA methylation signatures from gametes prime the establishment of accessible chromatin during zebrafish ZGA through two distinct mechanisms.
Sample scope Monoisolate
Release date 2021-03-10
Publication
PubMed ID Article title Journal name DOI Year
29844026 Inherited DNA methylation primes the establishment of accessible chromatin during genome activation Genome Research 10.1101/gr.228833.117 2018
Grants
Agency program Grant ID Grant title
Ministry of Science and Technology of the People's Republic of China (MOST) National Key Technologies R&D Program 2017YFA0102600
Ministry of Science and Technology of the People's Republic of China (MOST) National Key Technologies R&D Program 2016YFA0100400
National Natural Science Foundation of China (NSFC) Excellent Young Scientists Fund 31322031
National Natural Science Foundation of China (NSFC) General Program 31571365
National Natural Science Foundation of China (NSFC) General Program 31371288
National Natural Science Foundation of China (NSFC) Young Scientists Fund 31601161
Shanghai Science and Technology Committee (STCSM) Program of Shanghai Academic Research Leader 17XD1403600
Shanghai Science and Technology Committee (STCSM) Shanghai Municipal Science and Technology Commission 17ZR1449500
Accessions in other database
Accession Database name
PRJNA395463 NCBI
Submitter Yong    Zhang  (yzhang@tongji.edu.cn)
Organization Tongji University
Submission date 2021-03-10

Project Data

Resource name Description
BioSample (38)  show -
GSA (1) -
CRA004014 Inherited DNA methylation primes the establishment of accessible chromatin during genome activation
Related Projects
Projects (1)