| Accession |
PRJCA004721 |
| Title |
Mechanism study of Neural stem cell genome integrity |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
Raw sequence reads
|
| Organisms |
Mus musculus
Mus
|
| Description |
Endogenous DNA double-strand breaks (DSBs) formation and repair in neural stem/progenitor cells (NSPCs) play fundamental roles in neurogenesis and neurodevelopmental disorders. Here, we found that Filia is predominantly expressed in mouse hippocampal NSPCs after birth and regulates DNA DSB formation and repair via alternative splicing. |
| Sample scope |
Monoisolate |
| Release date |
2021-03-17 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 33115731
|
Genome integrity and neurogenesis of postnatal hippocampal neural stem/progenitor cells require a unique regulator Filia
|
Science Advances
|
10.1126/sciadv.aba0682.
|
2020
|
|
|
| Data provider |
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
National Key Technologies R&D Program
|
2016YFA0100300
|
|
|
|
| Submitter |
Qin
Baoming (qin_baoming@gibh.ac.cn)
|
| Organization |
Guangzhou Institutes of Biomedicine and Health (GIBH) |
| Submission date |
2021-03-16 |
