| Accession | PRJCA004742 | ||||||||||
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| Title | Mechanisms of early allograft dysfunction mediated by immunometabolism homeostasis imbalance | ||||||||||
| Relevance | Medical | ||||||||||
| Data types |
Whole genome sequencing
Transcriptome or Gene expression Genome sequencing and assembly Raw sequence reads Genome sequencing |
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| Organisms |
Mus musculus
Rattus Mus |
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| Description | Liver transplantation is an effective treatment for patients with end-stage liver diseases. The utilization of donors after cardiac death has significantly reduce the gap between patients on the waiting list and available donors since 2015. However, Chinese Liver Transplantation Registry has reported an increased incidence of early allograft dysfunction (EAD) in the meanwhile, which seriously affected graft survival and recipient prognosis. At present, most studies on EAD focused on ischemia-reperfusion injury (IRI), metabolic disorders and immune microenvironment alteration. But the molecular mechanism of EAD still remains unclear, which results in the lack of effective treatment strategies. Our previous studies have found that key metabolic pathways such as circFASN/miRNA-33/CPT1A in the donor graft were associated with postoperative metabolic disorders. After the procedure of ischemia-reperfusion, the dysregulation of these pathways would aggravate the metabolic disorders of hepatocytes and release metabolities, which further mediated the activation of NLRP3 inflammasome in macrophages and ultimately leaded to hepatocyte injury. Thus, the applicant found that the imbalance of immunometabolism homeostasis in donor grafts undergoing IRI contributed to the occurrence of EAD, and subsequently proposed the concept of "immunometabolism homeostasis-mediated EAD". The project will systematically study on the mechanism of EAD mediated by immunometabolism disorders after IRI, and develop a new treatment strategy based on novel nanodrugs to rebuild the homeostasis, which provides a new scientific basis for the prevention and intervention of EAD. | ||||||||||
| Sample scope | Single cell | ||||||||||
| Release date | 2021-03-18 | ||||||||||
| Publication |
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| Grants |
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| Submitter | Xinyu Yang (yangxinyuletters@163.com) | ||||||||||
| Organization | Zhejiang University | ||||||||||
| Submission date | 2021-03-18 |