| Accession |
PRJCA004774 |
| Title |
Changes of single-cell transcriptome during adult liver transplantation |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
|
| Organisms |
Homo sapiens
|
| Description |
Ischemia-reperfusion injury (IRI) remains the major reason for impaired donor graft function and increased mortality post-liver transplantation. The mechanism of IRI involves multiple pathophysiological processes and numerous types of cells. However, a systematic and comprehensive single-cell transcriptional profile of intrahepatic cells during liver transplantation is still unclear. In order to solve this problem, we used scRNA-seq to obtain the first unbiased and comprehensive liver transplant cell atlas by collecting liver tissue samples pre-procurement (PP), at the end of preservation (EP) and 2 h post-reperfusion (PR). All PP, EP, PR liver tissues were obtained from a 47-year-old male brain death donor. The recipient was a 51-year-old man with chronic hepatitis B virus infection and hepatocellular carcinoma. |
| Sample scope |
Single cell |
| Release date |
2021-03-22 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
81970564
|
|
|
|
| Submitter |
Zhiyong
Guo (rockyucsf1981@126.com)
|
| Organization |
The First Affiliated Hospital, Sun Yat-sen University |
| Submission date |
2021-03-21 |
