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Accession PRJCA004775
Title The roles of JMJD3 and KLF4 in reprogramming to pluripotency
Relevance stem cell reprogramming
Data types Epigenomics
Targeted Locus (Loci)
Transcriptome or Gene expression
Organisms Mus musculus
Description The interplay between the Yamanaka factors (OCT4, SOX2, KLF4 and c-MYC) and transcriptional/epigenetic co-regulators in somatic cell reprogramming is incompletely understood. Here, we demonstrate that the histone H3 lysine 27 trimethylation (H3K27me3) demethylase JMJD3 plays conflicting roles in mouse reprogramming. JMJD3 is specifically recruited by KLF4 to reduce H3K27me3 at both enhancers and promoters of epithelial and pluripotency genes. Our work, thus, establishes a multifaceted role for JMJD3, placing it as a key partner of KLF4 and a scaffold that assists chromatin interactions and activates gene transcription.
Sample scope Multiisolate
Release date 2021-05-13
Publication
PubMed ID Article title Journal name DOI Year
33033262
Grants
Agency program Grant ID Grant title
Ministry of Science and Technology of the People's Republic of China (MOST) National Key Technologies R&D Program 2016YFA0100300
Submitter Qin Baoming (qin_baoming@gibh.ac.cn)
Organization Guangzhou Institutes of Biomedicine and Health (GIBH)
Submission date 2021-03-22

Project Data

Resource name Description
BioSample (53)  show -
GSA (3) -
CRA004169 RNA-seq data of studying the roles of JMJD3 and KLF4 in reprogramming
CRA004165 ChIP-seq data of studying the roles of JMJD3 and KLF4 in reprogramming
CRA004171 ATAC-seq data of studying the roles of JMJD3 and KLF4 in reprogramming