| Accession |
PRJCA004834 |
| Title |
Genome-wide High Resolution Mapping of Mitotic DNA Synthesis Sites and Common Fragile Sites by Direct Sequencing [RNA-seq] |
| Relevance |
Medical |
| Data types |
Whole genome sequencing
Epigenomics
Transcriptome or Gene expression
Raw sequence reads
|
| Organisms |
Homo sapiens
|
| Description |
Common fragile sites (CFSs) are genomic loci prone to the formation of breaks or gaps on metaphase chromosomes. Here, we seek to map human CFSs with high resolution on a genome-wide scale by sequencing the sites of mitotic DNA synthesis (MiDASeq) that are specific for CFSs. We generated a nucleotide-resolution atlas of MiDAS sites (MDSs) that covered most of know CFSs, and comprehensively analyzed their sequence characteristics and genomic features. |
| Sample scope |
Monoisolate |
| Release date |
2021-03-30 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 32561861
|
Genome-wide high-resolution mapping of mitotic DNA synthesis sites and common fragile sites by direct sequencing
|
Cell Research
|
10.1038/s41422-020-0357-y
|
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
|
2016YFA0100300
|
|
|
|
| Submitter |
Qin
Baoming (qin_baoming@gibh.ac.cn)
|
| Organization |
Guangzhou Institutes of Biomedicine and Health (GIBH) |
| Submission date |
2021-03-30 |
