| Accession |
PRJCA004846 |
| Title |
A single-cell transcriptomic atlas of primate hippocampal aging |
| Relevance |
Model organism |
| Data types |
Transcriptome or Gene expression
|
| Organisms |
Macaca fascicularis
|
| Description |
In this study, we systemically depicted the aging-associated phenotypes of primate hippocampus, including the genome and epigenome instability, accumulation of protein aggregates and oxidative stress. Moreover, we established the first single-nucleus transcriptome atlas of primate hippocampal aging. By depicting the unique transcriptional profiles, we annotated 12 diverse cell types. Aging-related DEG analysis unraveled that neural transiently amplifying progenitor cells (TAPC) and microglia were the cell types most affected by aging manifested as the most DEGs and dysregulated neurodegenerative diseases-high risk genes. In-depth dissection of gene-expression dynamic signatures of neurogenic cell lineage revealed the impaired TAPC division and compromised neuronal maturation as well as synaptic plasticity as the prominent aging features along with the stepwise neurogenesis trajectory. Elevated pro-inflammatory response was observed in the aged microglia and oligodendrocyte, which may trigger the formation of an inflammaging microenvironment in the primate hippocampus. |
| Sample scope |
Single cell |
| Release date |
2021-06-01 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 34052996
|
Single-nucleus transcriptomic landscape of primate hippocampal aging
|
Protein & Cell
|
10.1007/s13238-021-00852-9
|
2021
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| No funding support
|
|
|
|
|
|
| Submitter |
Jiaming
Li (jiaming_li@foxmail.com)
|
| Organization |
Beijing Institute of Genomics, Chinese Academy of Sciences |
| Submission date |
2021-04-12 |
