| 项目编号 |
PRJCA004849 |
| 项目标题 |
Human corneal endothelial cells study |
| 涉及领域 |
Medical |
| 数据类型 |
Raw sequence reads
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Progressive loss of corneal endothelial cells during aging has been associated with the development of Fuchs endothelial corneal dystrophy (FECD), one of the main causes of cornea-related vision loss. The mechanisms underlying FECD development remain elusive. Single-cell RNA sequencing of isolated healthy human corneas discovered 4 subpopulations of corneal endothelial cells with distinctive signatures. Unsupervised clustering analysis uncovered nuclear enriched abundant transcript 1(NEAT1), a long non-coding RNA (lncRNA), as the top expressed gene, in the C0-endothelial subpopulation, but markedly downregulated in FECD. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2022-01-28 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 41060151
|
Comparative Transcriptomic Profiling of Corneal Compartments Using Single-Cell and Single-Nucleus Sequencing
|
Investigative Ophthalmology & Visual Science
|
10.1167/iovs.66.13.11
|
2025
|
| 35141048
|
Heterogeneity of human corneal endothelium implicates lncRNA NEAT1 in Fuchs endothelial corneal dystrophy
|
Molecular Therapy. Nucleic Acids
|
10.1016/j.omtn.2022.01.005
|
2022
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
81800876
|
|
| Natural Science Foundation of Shandong Province
|
|
ZR2019ZD37
|
|
| Natural Science Foundation of Shandong Province
|
|
ZR2019BH078
|
|
| Academic Promotion Programme of Shandong First Medical University
|
|
2019ZL001
|
|
| Academic Promotion Programme of Shandong First Medical University
|
|
2019RC008
|
|
| The Taishan Scholar Foundation of Shandong Province
|
|
20150215
|
|
| The Taishan Scholar Foundation of Shandong Province
|
|
20161059
|
|
|
|
| 提交者 |
Qun
Wang (wangqun8804@126.com)
|
| 提交单位 |
Shandong First Medical University |
| 提交日期 |
2021-04-13 |
