| Accession |
PRJCA004875 |
| Title |
Modeling SHANK3-associated Autism Spectrum Disorder in Beagle Dogs via CRISPR/Cas9 Gene Editing |
| Relevance |
Model organism |
| Data types |
Whole genome sequencing
|
| Organisms |
Canis lupus familiaris
|
| Description |
Domestic dog is an appealing alternative because of its complex and effective dog-human social interactions. In this study, we aimed to model ASD in experimental Beagle dogs by manipulating Shank3 gene, as SHANK3 mutations are commonly identified in ASD patients. By CRISPR/Cas9 gene editing, we successfully generated multiple lines of Beagle Shank3 (bShank3) mutants. |
| Sample scope |
Multiisolate |
| Release date |
2021-04-26 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 37848710
|
Modeling SHANK3-associated autism spectrum disorder in Beagle dogs via CRISPR/Cas9 gene editing
|
Molecular Psychiatry
|
10.1038/s41380-023-02276-9
|
2023
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Chinese Academy of Sciences (CAS)
|
Strategic Priority Research Program of Chinese Academy of Sciences (CAS)
|
XDBS1020100
|
|
| Chinese Academy of Sciences (CAS)
|
Strategic Priority Research Program of Chinese Academy of Sciences (CAS)
|
XDB32010300
|
|
| National Natural Science Foundation of China (NSFC)
|
|
31830036
|
|
| National Natural Science Foundation of China (NSFC)
|
|
31730039
|
|
| National Natural Science Foundation of China (NSFC)
|
|
31921002
|
|
|
|
| Submitter |
Zhao
Hui (zhaohui@genetics.ac.cn)
|
| Organization |
Institute of Genetics and Developmental Biology, Chinese Academy of Sciences |
| Submission date |
2021-04-26 |
