Accession

PRJCA004878

Title

Adenine base editor generates off-target mutations in monkey

Relevance

Medical

Data types

Whole genome sequencing
Transcriptome or Gene expression

Organisms

Macaca mulatta

Description

Somatic cell nuclear transfer embryo experiment facilitates revealing that adenine base editors can induce both DNA and RNA off-target mutations in the monkeys

Sample scope

Multiisolate

Release date

2022-08-03

Publication

PubMed ID	Article title	Journal name	DOI	Year
35867792	Cloning and base editing of GFP transgenic rhesus monkey and off-target analysis	Science Advances	10.1126/sciadv.abo3123	2022

Grants

Agency	program	Grant ID
Ministry of Science and Technology of the People's Republic of China (MOST)	National Key Research and Development Program	2016YFA0101401
Ministry of Science and Technology of the People's Republic of China (MOST)	National Key Research and Development Program	2018YFA0801400
Major Basic Research Project of Science and Technology of Yunnan	Major Basic Research Project of Science and Technology of Yunnan	202001BC070001

Submitter

shaoxing Dai (daishaoxing@163.com)

Organization

Institute of Primate Translational Medicine, Kunming University of Science and Technology

Submission date

2021-04-26

Project Data

Resource name	Description
BioSample (36) show	-
SAMC476475	Whole genome sequencing of monkey: SCNT blastocyst without ABE editing
SAMC476474	Whole genome sequencing of monkey: SCNT blastocyst without ABE editing
SAMC476473	Whole genome sequencing of monkey: SCNT blastocyst without ABE editing
SAMC476472	Whole genome sequencing of monkey: SCNT blastocyst without ABE editing
SAMC476471	Whole genome sequencing of monkey: SCNT blastocyst without ABE editing
SAMC476470	Whole genome sequencing of monkey: SCNT blastocyst without ABE editing
SAMC476469	Whole genome sequencing of monkey: newborn stomach with ABE editing
SAMC476468	Whole genome sequencing of monkey: newborn skin with ABE editing
SAMC476467	Whole genome sequencing of monkey: adult fibroblast without ABE editing
SAMC476466	Whole genome sequencing of monkey: adult fibroblast without ABE editing
SAMC476465	Whole genome sequencing of monkey: adult fibroblast without ABE editing
SAMC352096	RNA-seq of monkey: SCNT blastocyst without ABE editing
SAMC352095	RNA-seq of monkey: SCNT blastocyst without ABE editing
SAMC352094	RNA-seq of monkey: SCNT blastocyst without ABE editing
SAMC352093	RNA-seq of monkey: SCNT blastocyst without ABE editing
SAMC352092	RNA-seq of monkey: SCNT blastocyst without ABE editing
SAMC352091	RNA-seq of monkey: SCNT blastocyst with ABE editing
SAMC352090	RNA-seq of monkey: SCNT blastocyst with ABE editing
SAMC352089	RNA-seq of monkey: SCNT blastocyst with ABE editing
SAMC352088	RNA-seq of monkey: SCNT blastocyst with ABE editing
SAMC352087	RNA-seq of monkey: SCNT blastocyst with ABE editing
SAMC352086	Whole genome sequencing of monkey: SCNT blastocyst with ABE editing
SAMC352085	Whole genome sequencing of monkey: SCNT blastocyst with ABE editing
SAMC352084	Whole genome sequencing of monkey: SCNT blastocyst with ABE editing
SAMC352083	Whole genome sequencing of monkey: SCNT blastocyst with ABE editing
SAMC352082	Whole genome sequencing of monkey: SCNT blastocyst with ABE editing
SAMC352081	Whole genome sequencing of monkey: SCNT blastocyst with ABE editing
SAMC352080	Whole genome sequencing of monkey: SCNT blastocyst with ABE editing
SAMC352079	Whole genome sequencing of monkey: SCNT blastocyst with ABE editing
SAMC352078	Whole genome sequencing of monkey: SCNT blastocyst without ABE editing
SAMC352077	Whole genome sequencing of monkey: SCNT blastocyst without ABE editing
SAMC352076	Whole genome sequencing of monkey: SCNT blastocyst without ABE editing
SAMC352075	Whole genome sequencing of monkey: newborn muscle with ABE editing
SAMC352074	Whole genome sequencing of monkey: newborn stomach with ABE editing
SAMC352073	Whole genome sequencing of monkey: newborn skin with ABE editing
SAMC352072	Whole genome sequencing of monkey: adult fibroblast without ABE editing
GSA (1)	-
CRA004092	Adenine base editor generates off-target mutations in monkey