| 项目编号 |
PRJCA004981 |
| 项目标题 |
PRAD single-cell |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
To systematically explore genomic and transcriptomic intra-tumoral heterogeneity cooperate to shape the evolutionary course of prostate cancer ecosystem in primary tumor of un-treated PCa patients. A total of 14 surgically resected tissue samples were collected from patients with prostate cancer, which pathological type were prostatic acinar adenocarcinoma. No endocrine therapy was conducted on all patients before surgery. Cell capture and cDNA synthesis were carried out in 10X Genomics platform, and then transcriptome sequencing was performed in NovaSeq 6000 platform after meeting the all quality control. |
| 样品范围 |
Single cell |
| 发布日期 |
2022-08-08 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 35322584
|
Single-Cell RNA-seq Reveals a Developmental Hierarchy Super-Imposed Over Subclonal Evolution in the Cellular Ecosystem of Prostate Cancer
|
Advanced Science
|
10.1002/advs.202105530
|
2022
|
| 39137404
|
YAP1 Inhibition Induces Phenotype Switching of Cancer-Associated Fibroblasts to Tumor Suppressive in Prostate Cancer
|
Cancer Research
|
10.1158/0008-5472.CAN-24-0932
|
2024
|
| 39825401
|
Meta-analyses of mouse and human prostate single-cell transcriptomes reveal widespread epithelial plasticity in tissue regression, regeneration, and cancer
|
Genome Medicine
|
10.1186/s13073-025-01432-w
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Chinese Academy of Sciences (CAS)
|
Strategic Priority Research Program of Chinese Academy of Sciences (CAS)
|
XDA16010102
|
|
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
National Key Technologies R&D Program
|
2018YFC2000100
|
|
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
National Key Technologies R&D Program
|
2019YFA0110900
|
|
| Chinese Academy of Sciences (CAS)
|
|
QYZDB-SSW-SMC039
|
|
| National Natural Science Foundation of China (NSFC)
|
General Program
|
81672541
|
|
|
|
| 提交者 |
Weimin
ci (ciwm@big.ac.cn)
|
| 提交单位 |
Beijing Institute of Genomics, Chinese Academy of Sciences |
| 提交日期 |
2021-05-10 |
