| Accession |
PRJCA005089 |
| Title |
The first report of NUP214-ABL1 fusion gene in acute myeloid leukemia patient detected by next-generation sequencing |
| Relevance |
Medical |
| Data types |
Genome sequencing
|
| Organisms |
Homo sapiens
|
| Description |
The NUP214-ABL1 is a constitutively active tyrosine kinase that is found in 6% of T-cell acute lymphoblastic leukemia (T-ALL) patients; however the NUP214-ABL1 fusion in acute myeloid leukemia (AML) has not yet been reported. Up to now, the sensitivity of NUP214-ABL1-positive patients to tyrosine kinase inhibitor (TKI) is still controversial. Here we report the first case of an AML patient with NUP214-ABL1 fusion gene. The patient was successfully treated with conventional AML chemotherapy regimens. Identification of additional AML patients with NUP214-ABL1 fusion gene will provide treatment experience and prognostic evaluation. |
| Sample scope |
bone marrow |
| Release date |
2021-05-14 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 34307175
|
Case Report: The First Report of NUP214-ABL1 Fusion Gene in Acute Myeloid Leukemia Patient Detected by Next-Generation Sequencing
|
Frontiers in oncology
|
10.3389/fonc.2021.706798
|
2021
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| No funding support
|
|
|
|
|
|
| Submitter |
Jie
Jin (jiej0503@zju.edu.cn)
|
| Organization |
the First Affiliated Hospital, College of Medicine, Zhejiang University |
| Submission date |
2021-05-14 |
