| Accession |
PRJCA005170 |
| Title |
Integrated analysis of genomic and immunological features in lung adenocarcinoma with micropapillary component |
| Relevance |
Medical |
| Data types |
Variation
Genome sequencing
|
| Organisms |
Homo sapiens
|
| Description |
Micropapillary adenocarcinoma is one of the most aggressive histologic subtypes of lung adenocarcinoma (LADC), and even a minor proportion of micropapillary component (MPC) within the LADC could contribute to poor prognosis. Comprehensive analysis of genetic and immunological features of LADC with different percentages of MPC would help better understand cancer biology of this LADC subtype and direct future treatments. We performed next-generation sequencing (NGS) for a discovery cohort of 43 LADC patients whose tumors were microdissected to separate MPC and non-MPC lesions and a reference cohort of 113 LADC patients. MPC-enriched genetic alterations that were detected in the discovery cohort were then confirmed using a validation cohort of 183 LADC patients. Immunological staining was also conducted on the MPC-containing samples in the discovery cohort. |
| Sample scope |
Multiisolate |
| Release date |
2021-05-18 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 34221970
|
Integrated Analysis of Genomic and Immunological Features in Lung Adenocarcinoma With Micropapillary Component
|
Frontiers in Oncology
|
10.3389/fonc.2021.652193
|
2021
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
81773242
|
|
| Major project of Hangzhou Science and Technology Bureau
|
|
20180417A01
|
|
| Projects of Science and Technology Project of Hangzhou Bureau
|
|
20170533B28
|
|
| Projects of Science and Technology Project of Hangzhou Bureau
|
|
20180533B98
|
|
|
|
| Submitter |
Shirong
Zhang (shirleyz4444@zju.edu.cn)
|
| Organization |
Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine |
| Submission date |
2021-05-18 |
