| 项目编号 | PRJCA005199 | ||||||||||
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| 项目标题 | KDM2B regulates somatic reprogramming through PRC1 | ||||||||||
| 涉及领域 | Medical | ||||||||||
| 数据类型 |
Epigenomics
Transcriptome or Gene expression |
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| 物种名称 | Mus musculus | ||||||||||
| 描述信息 | In this project, we show that Kdm2b promotes Oct4-induced somatic reprogramming through recruitment of a variant PRC1 complex (PRC1.1) to CpG islands (CGIs). Furthermore, we find that bone morphogenetic protein (BMP) represses Oct4/ Kdm2b-induced somatic reprogramming selectively. Mechanistically, BMP-SMAD pathway attenuates PRC1.1 occupation and H2AK119 ubiquitination at genes linked to development, resulting in the expression of mesendodermal factors such as Sox17 and a consequent suppression of somatic reprogramming. | ||||||||||
| 样品范围 | Multiisolate | ||||||||||
| 发布日期 | 2021-05-25 | ||||||||||
| 出版信息 |
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| 项目资金来源 |
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| 提交者 | Lin Guo (guo_lin09@gibh.ac.cn) | ||||||||||
| 提交单位 | Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences | ||||||||||
| 提交日期 | 2021-05-19 |