| Accession |
PRJCA005250 |
| Title |
LINE-1 insulates chromatin in a transcription-dependent manner |
| Relevance |
Medical |
| Data types |
Whole genome sequencing
Epigenomics
Transcriptome or Gene expression
Raw sequence reads
|
| Organisms |
Homo sapiens
|
| Description |
Long INterspersed Element 1 (LINE-1 or L1), the only currently mobile autonomous transposon in humans, comprises 17% of the genome and is implicated in genome evolution, development and disease, but how L1 affects genome structure and gene expression remains unclear. In this study, we demonstrate that SAFB counteracts RNAPII accumulation in the L1 insulated chromatin topology and transcription, and illustrate how transposons interplay with transcription machineries and RNA-binding proteins to shape the genome architecture and transcription landscape. |
| Sample scope |
Monoisolate |
| Release date |
2021-09-30 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 38604171
|
SAFB restricts contact domain boundaries associated with L1 chimeric transcription
|
Molecular Cell
|
10.1016/j.molcel.2024.03.021
|
2024
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| No funding support
|
|
|
|
|
|
| Submitter |
Nian
Liu (liunian88@tsinghua.edu.cn)
|
| Organization |
Tsinghua University |
| Submission date |
2021-05-24 |
