| Description |
We performed single cell RNA-seq (scRNA-seq) and Whole Exome Sequencing (WES) on paired normal and tumor tissue of 14 treatment-naive intrahepatic cholangiocarcinoma (iCCA) patients. For scRNA-seq, after doublet removing, quality control for mitochondria percentage and UMI count, we got transcriptomic profiles of 144,878 single-cells, including malignant cells, fibrolasts, endothelial cells and immune cells such as T cell, B cell, NK and myeloid cells. Our study extends the understanding of the diversity of tumor cells in iCCA and provides clearer understanding of iCCA classification. |
