| Accession |
PRJCA005321 |
| Title |
The Histone Methyltransferase Setd2 Modulates Oxidative Stress to Attenuates Colonic Inflammation and Tumorigenesis |
| Relevance |
Medical |
| Data types |
Epigenomics
Raw sequence reads
Genome sequencing
|
| Organisms |
Mus musculus
|
| Description |
Epithelial barrier disruption is one of the major causes of inflammatory bowel disease (IBD) in which epigenetic modulations are pivotal elements. However, the epigenetic mechanisms underlying the epithelial barrier integrity regulation remain largely unexplored. Here, we investigated how SETD2, a histone H3K36 trimethyltransferase, maintains intestinal epithelial homeostasis. |
| Sample scope |
Multiisolate |
| Release date |
2021-05-31 |
| Publication |
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
|
2017YFA0102900
|
|
|
|
| Submitter |
Weiqiang
Gao (gao.weiqiang@sjtu.edu.cn)
|
| Organization |
Shanghai Jiao Tong University |
| Submission date |
2021-05-31 |
