| 项目编号 | PRJCA005334 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 项目标题 | Inter-determination of blood metabolite levels and gut microbiome supported by Mendelian randomization | ||||||||
| 涉及领域 | Medical | ||||||||
| 数据类型 |
Metagenome
Variation metabolome |
||||||||
| 物种名称 |
Homo sapiens
human gut metagenome |
||||||||
| 描述信息 | The gut microbiome has been implicated in a variety of physiological states. Controversy over causality, however, has always haunted microbiome studies. Here, we utilized the bidirectional Mendelian randomization (MR) approach to address questions that are not yet mature for more costly randomized interventions. From a total of 3,432 Chinese individuals with shotgun sequencing data for whole genome and whole metagenome, as well as anthropometric and blood metabolic traits, we identified 58 causal relationships between the gut microbiome and blood metabolites, and replicated 43 out of the 58. This study illustrates the value of human genetic information to help prioritize gut microbial features for mechanistic and clinical studies. The results are consistent with whole-body cross-talks of the microbiome and the circulating molecules. | ||||||||
| 样品范围 | Multispecies | ||||||||
| 发布日期 | 2021-06-01 | ||||||||
| 项目资金来源 |
|
||||||||
| 提交者 | zhang tao (tao.zhang@genomics.cn) | ||||||||
| 提交单位 | BGI | ||||||||
| 提交日期 | 2021-06-01 |
| 资源名称 | 描述 |
|---|---|
| BioSample (8522) show | - |