| Accession | PRJCA005334 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Title | Inter-determination of blood metabolite levels and gut microbiome supported by Mendelian randomization | ||||||||
| Relevance | Medical | ||||||||
| Data types |
Metagenome
Variation metabolome |
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| Organisms |
Homo sapiens
human gut metagenome |
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| Description | The gut microbiome has been implicated in a variety of physiological states. Controversy over causality, however, has always haunted microbiome studies. Here, we utilized the bidirectional Mendelian randomization (MR) approach to address questions that are not yet mature for more costly randomized interventions. From a total of 3,432 Chinese individuals with shotgun sequencing data for whole genome and whole metagenome, as well as anthropometric and blood metabolic traits, we identified 58 causal relationships between the gut microbiome and blood metabolites, and replicated 43 out of the 58. This study illustrates the value of human genetic information to help prioritize gut microbial features for mechanistic and clinical studies. The results are consistent with whole-body cross-talks of the microbiome and the circulating molecules. | ||||||||
| Sample scope | Multispecies | ||||||||
| Release date | 2021-06-01 | ||||||||
| Grants |
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| Submitter | zhang tao (tao.zhang@genomics.cn) | ||||||||
| Organization | BGI | ||||||||
| Submission date | 2021-06-01 |
| Resource name | Description |
|---|---|
| BioSample (8522) show | - |