| Accession |
PRJCA005353 |
| Title |
WGBS and RNA-Seq for anxiety behavior |
| Relevance |
Medical |
| Data types |
Epigenomics
Transcriptome or Gene expression
|
| Organisms |
Mus musculus
|
| Description |
Pathophysiological mechanisms for depression/anxiety are largely unknown. Evidence for transgenerational transmission of acquired epigenetic marks remains limited. We bred unstressed (US) female mice with adolescently restraint-stressed (RS), social instability-stressed (SI) or US males to produce RS, SI and control F1 offspring, respectively. Next-generation sequencing and bioinformatics using RS and SI female offspring identified 5 candidate anxiety-transmitting (CAT) genes; each showed a consistent pattern of DNA methylation from F0 spermatozoa through F1 blastocysts to fetal and adult hippocampi. Further analyses validated 4 CAT genes, demonstrated that paternal SI caused ALB differences between male and female offspring through modifying the CAT genes, and indicated a strong correlation between inflammation and ALB pathogenesis and an important function for intronic DNA methylation in regulating ALB-related genes. |
| Sample scope |
Multiisolate |
| Release date |
2021-10-11 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 28000794
|
|
|
|
|
| 35790809
|
A next-generation sequencing study on mechanisms by which restraint and social instability stresses of male mice alter offspring anxiety-like behavior
|
Scientific Reports
|
10.1038/s41598-021-87060-x
|
2021
|
| 35790809
|
Author Correction: A next-generation sequencing study on mechanisms by which restraint and social instability stresses of male mice alter offspring anxiety-like behavior
|
Scientific Reports
|
10.1038/s41598-022-15820-4
|
2022
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
31772599
|
|
| National Natural Science Foundation of China (NSFC)
|
|
31702114
|
|
|
|
| Submitter |
Qiaoqiao
Kong (kongqiao00@163.com)
|
| Organization |
Shandong Agricultural University |
| Submission date |
2021-06-02 |
