Accession PRJCA005353
Title WGBS and RNA-Seq for anxiety behavior
Relevance Medical
Data types Epigenomics
Transcriptome or Gene expression
Organisms Mus musculus
Description Pathophysiological mechanisms for depression/anxiety are largely unknown. Evidence for transgenerational transmission of acquired epigenetic marks remains limited. We bred unstressed (US) female mice with adolescently restraint-stressed (RS), social instability-stressed (SI) or US males to produce RS, SI and control F1 offspring, respectively. Next-generation sequencing and bioinformatics using RS and SI female offspring identified 5 candidate anxiety-transmitting (CAT) genes; each showed a consistent pattern of DNA methylation from F0 spermatozoa through F1 blastocysts to fetal and adult hippocampi. Further analyses validated 4 CAT genes, demonstrated that paternal SI caused ALB differences between male and female offspring through modifying the CAT genes, and indicated a strong correlation between inflammation and ALB pathogenesis and an important function for intronic DNA methylation in regulating ALB-related genes.
Sample scope Multiisolate
Release date 2021-10-11
Publication
PubMed ID Article title Journal name DOI Year
28000794
Grants
Agency program Grant ID Grant title
National Natural Science Foundation of China (NSFC) 31772599
National Natural Science Foundation of China (NSFC) 31702114
Submitter Qiaoqiao    Kong  (kongqiao00@163.com)
Organization Shandong Agricultural University
Submission date 2021-06-02

Project Data

Resource name Description
BioSample (12)  show -
GSA (1) -
CRA004404 WGBS for anxiety behavior