| Accession |
PRJCA005449 |
| Title |
Genomic and epigenomic evolution of acquired resistance to chemotherapy combined with verapamil in esophageal squamous cell carcinoma |
| Relevance |
Medical |
| Data types |
Raw sequence reads
|
| Organisms |
Homo sapiens
|
| Description |
Targeted arterial infusion of verapamil combined with chemotherapy (TVCC) is an effective clinical interventional therapy for esophageal squamous cell carcinoma (ESCC), but multidrug resistance (MDR) remains the major cause of relapse or poor prognosis, and the underlying molecular mechanisms of MDR, temporal intratumoral heterogeneity and clonal evolutionary processes of resistance have not been determined. To elucidate the roles of genetic and epigenetic alterations in evolution of acquired resistance during therapies, we performed whole-exome sequencing and whole-genome bisulfite sequencing for 7 patients. Our integrated multi-omics investigations reveal the dynamics of temporal genetic and epigenetic inter- and intratumoral heterogeneity, clonal evolutionary processes and epigenomic changes, providing potential MDR therapeutic targets in treatment-resistant ESCC patients during combined therapies. |
| Sample scope |
Multiisolate |
| Release date |
2021-06-15 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
81988101
|
|
| National Natural Science Foundation of China (NSFC)
|
|
81830086
|
|
| National Natural Science Foundation of China (NSFC)
|
|
82003007
|
|
| Science Foundation of Peking University Cancer Hospital
|
|
17-01
|
|
| Science Foundation of Peking University Cancer Hospital
|
|
2020-16
|
|
| CAMS Innovation Fund for Medical Sciences
|
|
2019-I2M-5-081
|
|
| Major Program of Shenzhen Bay Laboratory
|
|
S201101004
|
|
| Guangdong Basic and Applied Basic Research Foundation
|
|
2019B030302012
|
|
| Beijing Municipal Medical Research Institutes
|
|
2019-1
|
|
|
|
| Submitter |
Qimin
Zhan (zhanqimin@bjmu.edu.cn)
|
| Organization |
Peking University Cancer Hospital & Institute |
| Submission date |
2021-06-12 |
