Accession |
PRJCA005479 |
Title |
Genomic and epignomic evolution of acquired resistance to chemotherapy combined with verapamil in ESCC |
Relevance |
Medical |
Data types |
Exome
|
Organisms |
Homo sapiens
|
Description |
Targeted arterial infusion of verapamil combined with chemotherapy (TVCC) is an effective clinical interventional therapy for esophageal squamous cell carcinoma (ESCC), but multidrug resistance (MDR) remains the major cause of relapse or poor prognosis, and the underlying molecular mechanisms of MDR, temporal intratumoral heterogeneity and clonal evolutionary processes of resistance have not been determined. |
Sample scope |
Multiisolate |
Release date |
2021-06-15 |
Publication |
PubMed ID |
Article title |
Journal name |
DOI |
Year |
34494553
|
Genomic and epigenomic evolution of acquired resistance to combination therapy in esophageal squamous cell carcinoma
|
JCI Insight
|
10.1172/jci.insight.150203
|
2021
|
|
Grants |
Agency |
program |
Grant ID |
Grant title |
National Natural Science Foundation of China (NSFC)
|
|
81988101
|
|
National Natural Science Foundation of China (NSFC)
|
|
81830086
|
|
National Natural Science Foundation of China (NSFC)
|
|
82003007
|
|
Science Foundation of Peking University Cancer Hospital
|
|
17-01
|
|
Science Foundation of Peking University Cancer Hospital
|
|
2020-16
|
|
CAMS Innovation Fund for Medical Sciences
|
|
2019-I2M-5-081
|
|
Major Program of Shenzhen Bay Laboratory
|
|
S201101004
|
|
Guangdong Basic and Applied Basic Research Foundation
|
|
2019B030302012
|
|
Beijing Medical Research Institute
|
|
2019-1
|
|
|
Submitter |
Qimin
Zhan (zhanqimin@bjmu.edu.cn)
|
Organization |
Peking University Cancer Hospital & Institute |
Submission date |
2021-06-15 |