Accession PRJCA005479
Title Genomic and epignomic evolution of acquired resistance to chemotherapy combined with verapamil in ESCC
Relevance Medical
Data types Exome
Organisms Homo sapiens
Description Targeted arterial infusion of verapamil combined with chemotherapy (TVCC) is an effective clinical interventional therapy for esophageal squamous cell carcinoma (ESCC), but multidrug resistance (MDR) remains the major cause of relapse or poor prognosis, and the underlying molecular mechanisms of MDR, temporal intratumoral heterogeneity and clonal evolutionary processes of resistance have not been determined.
Sample scope Multiisolate
Release date 2021-06-15
Publication
PubMed ID Article title Journal name DOI Year
34494553 Genomic and epigenomic evolution of acquired resistance to combination therapy in esophageal squamous cell carcinoma JCI Insight 10.1172/jci.insight.150203 2021
Grants
Agency program Grant ID Grant title
National Natural Science Foundation of China (NSFC) 81988101
National Natural Science Foundation of China (NSFC) 81830086
National Natural Science Foundation of China (NSFC) 82003007
Science Foundation of Peking University Cancer Hospital 17-01
Science Foundation of Peking University Cancer Hospital 2020-16
CAMS Innovation Fund for Medical Sciences 2019-I2M-5-081
Major Program of Shenzhen Bay Laboratory S201101004
Guangdong Basic and Applied Basic Research Foundation 2019B030302012
Beijing Medical Research Institute 2019-1
Submitter Qimin    Zhan  (zhanqimin@bjmu.edu.cn)
Organization Peking University Cancer Hospital & Institute
Submission date 2021-06-15

Project Data

Resource name Description
BioSample (28)  show -