项目编号 PRJCA005481
项目标题 The associations between human sperm DNA fragmentation and DNA methylation
涉及领域 Medical
数据类型 Epigenomics
Raw sequence reads
物种名称 Homo sapiens
描述信息 It is widely accepted that sperm DNA integrity is imperative for successful fertilization, embryo development and pregnancy (1). High percentage of DNA damaged sperm cells was found in infertile men and negatively affects paternal reproductive capacity. There is a clear association between high level of sperm DNA damage in male and high risk of mutational load or morbidity in the offspring especially in aged or smoking men. As a manifest of sperm DNA damage, sperm DNA fragmentation (SDF) has attracted considerable interest in male infertility research and clinical andrology. SDF is a complicated disorder with diverse associations with genetic, medical, environmental and lifestyle factors that dynamically alter the disorder. DNA methylation is the most studied epigenetic mechanism and emerging as promising frontier in comprehending the epigenetic nature of human sperm.
样品范围 Multiisolate
发布日期 2023-06-15
项目资金来源
机构 项目类型 授权项目ID 授权项目名称
National Natural Science Foundation of China (NSFC) 81903293
提交者 Wuhua Ni (niwuhua228@163.com)
提交单位 the First Affiliated Hospital of Wenzhou Medical University
提交日期 2021-06-15

项目包含数据信息

资源名称 描述
BioSample (267)  show -