| Accession |
PRJCA005546 |
| Title |
Whole-exome sequencing on circulating tumor cells explores platinum-drug resistance mutations in advanced non-small cell lung cancer |
| Relevance |
Medical |
| Data types |
Whole genome sequencing
|
| Organisms |
Homo sapiens
|
| Description |
Circulating tumor cells (CTCs) have important applications in clinical practice on early tumor diagnosis, prognostic prediction and treatment evaluation. Platinum-based chemotherapy is a fundamental treatment for non-small cell lung cancer (NSCLC) patients who are not suitable for targeted drug therapies. However, most patients progressed after a period of treatment. Therefore, to reveal the genetic information contributing to drug resistance and tumor metastasis in CTCs is valuable for treatment adjustment. |
| Sample scope |
Multiisolate |
| Release date |
2021-06-21 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 34616428
|
Whole-Exome Sequencing on Circulating Tumor Cells Explores Platinum-Drug Resistance Mutations in Advanced Non-small Cell Lung Cancer
|
Frontiers in Genetics
|
10.3389/fgene.2021.722078
|
2021
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
N/A
|
|
|
|
| Submitter |
Rong
Li (xkyylirong@163.com)
|
| Organization |
Shanghai Chest Hospital |
| Submission date |
2021-06-21 |
