| Accession | PRJCA005548 | ||||||||
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| Title | Global brain protection evaluation system and translational research after acute focal cerebral ischemia | ||||||||
| Relevance | Medical | ||||||||
| Data types | Evaluation system | ||||||||
| Organisms |
Rattus
Mus Homo Platyrrhini |
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| Description | Acute cerebral ischemia is a major chronic disease that causes death and disability. Intravenous thrombolysis or intravascular stent thrombus removal is the only treatment recommended by the current international evidence-based guidelines. It can recanalize the occluded blood vessel and save the ischemic penumbra. It brings and improves nerve function, but its treatment time window is narrow, and only a few patients benefit. For decades, neuroprotection has been placed high hopes as another important treatment strategy for cerebral ischemia. It has always been a hotspot in the research of cerebral ischemia injury. Little attention has been paid to the secondary damage to the remote site with fiber connection and its impact on the whole brain function. Almost all neuroprotective drugs that have been proven effective in rodent models have failed after entering clinical trials. However, in clinical practice in my country, these neuroprotective agents lacking evidence-based medical evidence are still widely used, and their rationality is highly controversial. The species differences between rodents and human brain structures and functions, single-center studies, small sample sizes, limited evaluation indicators, and ignorance of global brain function, are considered to be important reasons for the failure of clinical transformation of neuroprotective agents. Therefore, the establishment of cerebral infarction animal models that are closer to human disease conditions, the use of more objective and comprehensive evaluation indicators, and the development of multi-center research on the local and global brain damage mechanisms and neuroprotection of the infarct focus are problems that need to be solved urgently. | ||||||||
| Sample scope | Multispecies | ||||||||
| Release date | 2021-09-01 | ||||||||
| Grants |
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| Submitter | Jinsheng Zeng (zengjsh@mail.sysu.edu.cn) | ||||||||
| Organization | Sun Yat-sen University | ||||||||
| Submission date | 2021-06-21 |
| Resource name | Description |
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