| Accession |
PRJCA005577 |
| Title |
Single cell RNA sequencing of mouse lung cancer-associated fibroblasts with chemotherapy |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
Raw sequence reads
|
| Organisms |
Mus musculus
|
| Description |
We aimed to compare the alterations of fibroblast subtypes after chemoterapy in lung cancer. For this purpose, we transplanted lung cancer cell line LLC to EGFP-C57BL/6 mice and treated the mice with doxorubicin. After treatment, EGFP+CD45- stromal cells in the tumor were sorted and mixed from 3 treated or control mice for single cell RNA sequecing. The sequencing data was analysed and fibroblast subtypes were identified and compared. |
| Sample scope |
Single cell |
| Release date |
2022-08-31 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 36207295
|
ZIP1+ fibroblasts protect lung cancer against chemotherapy via connexin-43 mediated intercellular Zn2+ transfer
|
Nature Communications
|
10.1038/s41467-022-33521-4
|
2022
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
81630068
|
|
| National Natural Science Foundation of China (NSFC)
|
|
81902336
|
|
|
|
| Submitter |
Chen
Ni (nichen904@163.com)
|
| Organization |
The First Affiliated Hospital of Zhengzhou University |
| Submission date |
2021-06-23 |
