| 项目编号 |
PRJCA005577 |
| 项目标题 |
Single cell RNA sequencing of mouse lung cancer-associated fibroblasts with chemotherapy |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
Raw sequence reads
|
| 物种名称 |
Mus musculus
|
| 描述信息 |
We aimed to compare the alterations of fibroblast subtypes after chemoterapy in lung cancer. For this purpose, we transplanted lung cancer cell line LLC to EGFP-C57BL/6 mice and treated the mice with doxorubicin. After treatment, EGFP+CD45- stromal cells in the tumor were sorted and mixed from 3 treated or control mice for single cell RNA sequecing. The sequencing data was analysed and fibroblast subtypes were identified and compared. |
| 样品范围 |
Single cell |
| 发布日期 |
2022-08-31 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 36207295
|
ZIP1+ fibroblasts protect lung cancer against chemotherapy via connexin-43 mediated intercellular Zn2+ transfer
|
Nature Communications
|
10.1038/s41467-022-33521-4
|
2022
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
81630068
|
|
| National Natural Science Foundation of China (NSFC)
|
|
81902336
|
|
|
|
| 提交者 |
Chen
Ni (nichen904@163.com)
|
| 提交单位 |
The First Affiliated Hospital of Zhengzhou University |
| 提交日期 |
2021-06-23 |
