| Accession |
PRJCA005588 |
| Title |
Postmortem high-dimensional immune profiling of severe COVID-19 patients reveals distinct patterns of immunosuppression in multiple organs |
| Relevance |
immunity |
| Data types |
Transcriptome or Gene expression
|
| Organisms |
Homo sapiens
|
| Description |
A complete diagnostic autopsy is the gold-standard to gain insight into Coronavirus disease 2019 (COVID-19) pathogenesis. To delineate the in situ immune responses to SARS-CoV-2 viral infection, we performed comprehensive high-dimensional immune profiling in 22 COVID-19 decedents from Wuhan, China. We first identified TIM-3- and PD-1-mediated immunosuppression as a hallmark of severe COVID-19, particularly in men. Next, we observed that PD-1+ cells were proximal rather than distal to TIM-3+ cells and that lymphocytes were distal rather than proximal to SARS-CoV-2 viral antigens. Additionally, activated myeloid cells were found in close proximity to SARS-CoV-2 viral antigens. Indeed, most infected cells across multiple organs were myeloid cells. We subsequently demonstrated a positive correlation between viral load and immunosuppression and dendritic cell markers. SARS-CoV-2 viral infection induces lymphocyte suppression yet myeloid activation in severe COVID-19. We should thus consider the two immune compartments separately when investigating disease progression |
| Sample scope |
Multiisolate |
| Release date |
2021-12-01 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 35022412
|
Postmortem high-dimensional immune profiling of severe COVID-19 patients reveals distinct patterns of immunosuppression and immunoactivation
|
Nature Communications
|
10.1038/s41467-021-27723-5
|
2022
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
N/A
|
|
|
|
| Submitter |
Cheng
Sun (charless@ustc.edu.cn)
|
| Organization |
University of Science and Technology of China |
| Submission date |
2021-06-24 |
