| Accession |
PRJCA005902 |
| Title |
Human keratoconus m6A study |
| Relevance |
Medical |
| Data types |
Epigenomics
Arraystar Epitranscriptomic microarray
|
| Organisms |
Homo
|
| Description |
Keratoconus (KC) is an asymmetric, progressive ectasia that can lead to severe visual impairment. Despite the high prevalence of the disease, the molecular mechanisms underlying the disease are poorly understood. Here, we analyzed tissues from normal and KC corneas by m6a microarray. Our data showed that the level of m6a modification was significantly altered in cone corneas compared to controls, while KC showed increased inflammation. In conclusion, our corneal tissue data in steady state and disease states provide a unique resource for identifying genes that may contribute to KC and for better understanding and treatment of KC. |
| Sample scope |
Monoisolate |
| Release date |
2023-07-20 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Academic Promotion Programme of Shandong First Medical University
|
|
2019RC009
|
|
| The Taishan Scholar Foundation of Shandong Province
|
|
201812150
|
|
| National Natural Science Foundation of China (NSFC)
|
|
82070923
|
|
|
|
| Submitter |
Hua
Gao (hgao@sdfmu.edu.cn)
|
| Organization |
Shandong First Medical University |
| Submission date |
2021-07-19 |
