| Accession |
PRJCA005935 |
| Title |
Peripheral nerve injury induced cell-types dependent transcriptomic changes in the retrosplenial cortex |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
|
| Organisms |
Mus musculus
|
| Description |
The retrosplenial cortex (RSC) processes nociceptive information, and it presents structural and molecular changes after nerve injury. In contrast, the detailed transcriptional changes in the RSC were unknown. Here we confirmed the involvements of RSC in the regulation of pain sensation and observed that the same peripheral stimulation activated more splenial neurons after nerve injury. Using a single-cell RNA-sequencing (scRNA-seq) approach, we identified the cell-type-specific differential expression genes (DEGs) that may convey the cell-type dependent functional impairments. |
| Sample scope |
Single cell |
| Release date |
2023-12-01 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 38048224
|
Single-cell RNA sequencing uncovers the cell type-dependent transcriptomic changes in the retrosplenial cortex after peripheral nerve injury
|
Cell Reports
|
10.1016/j.celrep.2023.113551
|
2023
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
31871062
|
|
|
|
| Submitter |
Cheng
Wu (11818295@zju.edu.cn)
|
| Organization |
Zhejiang University |
| Submission date |
2021-07-25 |
