Accession

PRJCA006001

Title

Aberrant gut-metabolome-immune network in schizophrenia

Relevance

Medical

Data types

Metagenome

Organisms

human gut metagenome

Description

Although schizophrenia (SCZ) has been associated with dramatic changes in the gut microbiome and serum metabolome, the molecular interface between the host and microbiota is poorly understood. To address this, we performed an integrative analysis of intestinal microbiota, serum metabolome, and serum inflammatory cytokines in SCZ patients and controls using a multi-omics strategy. Sixty-three SCZ patients and 57 healthy controls were enrolled in the study. Liquid chromatography-mass spectrometry and bead-based multiplex cytokine assays were performed simultaneously on serum samples, and shotgun metagenomic sequencing was used to evaluate the gut microbial composition and functional potential.

Sample scope

Multispecies

Release date

2021-08-04

Publication

PubMed ID	Article title	Journal name	DOI	Year
35309369	Multi-Omics Analysis Reveals Aberrant Gut-Metabolome-Immune Network in Schizophrenia	Frontiers in Immunology	10.3389/fimmu.2022.812293	2022

Grants

Agency	program	Grant ID	Grant title
National Natural Science Foundation of China (NSFC)		81771471

Submitter

Yajuan Fan (1591582705@qq.com)

Organization

The First Affiliated Hospital of Xi'an Jiaotong University

Submission date

2021-08-01

Project Data

Resource name	Description
BioSample (120) show	-
SAMC439163	Shotgun metagenomic sequencing of human fecal C57
SAMC439162	Shotgun metagenomic sequencing of human fecal C56
SAMC439161	Shotgun metagenomic sequencing of human fecal C55
SAMC439160	Shotgun metagenomic sequencing of human fecal C54
SAMC439159	Shotgun metagenomic sequencing of human fecal C53
SAMC439158	Shotgun metagenomic sequencing of human fecal C52
SAMC439157	Shotgun metagenomic sequencing of human fecal C51
SAMC439156	Shotgun metagenomic sequencing of human fecal C50
SAMC439155	Shotgun metagenomic sequencing of human fecal C49
SAMC439154	Shotgun metagenomic sequencing of human fecal C48
SAMC439153	Shotgun metagenomic sequencing of human fecal C47
SAMC439152	Shotgun metagenomic sequencing of human fecal C46
SAMC439151	Shotgun metagenomic sequencing of human fecal C45
SAMC439150	Shotgun metagenomic sequencing of human fecal C44
SAMC439149	Shotgun metagenomic sequencing of human fecal C43
SAMC439148	Shotgun metagenomic sequencing of human fecal C42
SAMC439147	Shotgun metagenomic sequencing of human fecal C41
SAMC439146	Shotgun metagenomic sequencing of human fecal C40
SAMC439145	Shotgun metagenomic sequencing of human fecal C39
SAMC439144	Shotgun metagenomic sequencing of human fecal C38
SAMC439143	Shotgun metagenomic sequencing of human fecal C37
SAMC439142	Shotgun metagenomic sequencing of human fecal C36
SAMC439141	Shotgun metagenomic sequencing of human fecal C35
SAMC439140	Shotgun metagenomic sequencing of human fecal C34
SAMC439139	Shotgun metagenomic sequencing of human fecal C33
SAMC439138	Shotgun metagenomic sequencing of human fecal C32
SAMC439137	Shotgun metagenomic sequencing of human fecal C31
SAMC439136	Shotgun metagenomic sequencing of human fecal C30
SAMC439135	Shotgun metagenomic sequencing of human fecal C29
SAMC439134	Shotgun metagenomic sequencing of human fecal C28
SAMC439133	Shotgun metagenomic sequencing of human fecal C27
SAMC439132	Shotgun metagenomic sequencing of human fecal C26
SAMC439131	Shotgun metagenomic sequencing of human fecal C25
SAMC439130	Shotgun metagenomic sequencing of human fecal C24
SAMC439129	Shotgun metagenomic sequencing of human fecal C23
SAMC439128	Shotgun metagenomic sequencing of human fecal C22
SAMC439127	Shotgun metagenomic sequencing of human fecal C21
SAMC439126	Shotgun metagenomic sequencing of human fecal C20
SAMC439125	Shotgun metagenomic sequencing of human fecal C19
SAMC439124	Shotgun metagenomic sequencing of human fecal C18
SAMC439123	Shotgun metagenomic sequencing of human fecal C17
SAMC439122	Shotgun metagenomic sequencing of human fecal C16
SAMC439121	Shotgun metagenomic sequencing of human fecal C15
SAMC439120	Shotgun metagenomic sequencing of human fecal C14
SAMC439119	Shotgun metagenomic sequencing of human fecal C13
SAMC439118	Shotgun metagenomic sequencing of human fecal C12
SAMC439117	Shotgun metagenomic sequencing of human fecal C11
SAMC439116	Shotgun metagenomic sequencing of human fecal C10
SAMC439115	Shotgun metagenomic sequencing of human fecal C9
SAMC439114	Shotgun metagenomic sequencing of human fecal C8
SAMC439113	Shotgun metagenomic sequencing of human fecal C7
SAMC439112	Shotgun metagenomic sequencing of human fecal C6
SAMC439111	Shotgun metagenomic sequencing of human fecal C5
SAMC439110	Shotgun metagenomic sequencing of human fecal C4
SAMC439109	Shotgun metagenomic sequencing of human fecal C3
SAMC439108	Shotgun metagenomic sequencing of human fecal C2
SAMC439107	Shotgun metagenomic sequencing of human fecal C1
SAMC439106	Shotgun metagenomic sequencing of human fecal S63
SAMC439105	Shotgun metagenomic sequencing of human fecal S62
SAMC439104	Shotgun metagenomic sequencing of human fecal S61
SAMC439103	Shotgun metagenomic sequencing of human fecal S60
SAMC439102	Shotgun metagenomic sequencing of human fecal S59
SAMC439101	Shotgun metagenomic sequencing of human fecal S58
SAMC439100	Shotgun metagenomic sequencing of human fecal S57
SAMC439099	Shotgun metagenomic sequencing of human fecal S56
SAMC439098	Shotgun metagenomic sequencing of human fecal S55
SAMC439097	Shotgun metagenomic sequencing of human fecal S54
SAMC439096	Shotgun metagenomic sequencing of human fecal S53
SAMC439095	Shotgun metagenomic sequencing of human fecal S52
SAMC439094	Shotgun metagenomic sequencing of human fecal S51
SAMC439093	Shotgun metagenomic sequencing of human fecal S50
SAMC439092	Shotgun metagenomic sequencing of human fecal S49
SAMC439091	Shotgun metagenomic sequencing of human fecal S48
SAMC439090	Shotgun metagenomic sequencing of human fecal S47
SAMC439089	Shotgun metagenomic sequencing of human fecal S46
SAMC439088	Shotgun metagenomic sequencing of human fecal S45
SAMC439087	Shotgun metagenomic sequencing of human fecal S44
SAMC439086	Shotgun metagenomic sequencing of human fecal S43
SAMC439085	Shotgun metagenomic sequencing of human fecal S42
SAMC439084	Shotgun metagenomic sequencing of human fecal S41
SAMC439083	Shotgun metagenomic sequencing of human fecal S40
SAMC439082	Shotgun metagenomic sequencing of human fecal S39
SAMC439081	Shotgun metagenomic sequencing of human fecal S38
SAMC439080	Shotgun metagenomic sequencing of human fecal S37
SAMC439079	Shotgun metagenomic sequencing of human fecal S36
SAMC439078	Shotgun metagenomic sequencing of human fecal S35
SAMC439077	Shotgun metagenomic sequencing of human fecal S34
SAMC439076	Shotgun metagenomic sequencing of human fecal S33
SAMC439075	Shotgun metagenomic sequencing of human fecal S32
SAMC439074	Shotgun metagenomic sequencing of human fecal S31
SAMC439073	Shotgun metagenomic sequencing of human fecal S30
SAMC439072	Shotgun metagenomic sequencing of human fecal S29
SAMC439071	Shotgun metagenomic sequencing of human fecal S28
SAMC439070	Shotgun metagenomic sequencing of human fecal S27
SAMC439069	Shotgun metagenomic sequencing of human fecal S26
SAMC439068	Shotgun metagenomic sequencing of human fecal S25
SAMC439067	Shotgun metagenomic sequencing of human fecal S24
SAMC439066	Shotgun metagenomic sequencing of human fecal S23
SAMC439065	Shotgun metagenomic sequencing of human fecal S22
SAMC439064	Shotgun metagenomic sequencing of human fecal S21
SAMC439063	Shotgun metagenomic sequencing of human fecal S20
SAMC439062	Shotgun metagenomic sequencing of human fecal S19
SAMC439061	Shotgun metagenomic sequencing of human fecal S18
SAMC439060	Shotgun metagenomic sequencing of human fecal S17
SAMC439059	Shotgun metagenomic sequencing of human fecal S16
SAMC439058	Shotgun metagenomic sequencing of human fecal S15
SAMC439057	Shotgun metagenomic sequencing of human fecal S14
SAMC439056	Shotgun metagenomic sequencing of human fecal S13
SAMC439055	Shotgun metagenomic sequencing of human fecal S12
SAMC439054	Shotgun metagenomic sequencing of human fecal S11
SAMC439053	Shotgun metagenomic sequencing of human fecal S10
SAMC439052	Shotgun metagenomic sequencing of human fecal S9
SAMC439051	Shotgun metagenomic sequencing of human fecal S8
SAMC439050	Shotgun metagenomic sequencing of human fecal S7
SAMC439049	Shotgun metagenomic sequencing of human fecal S6
SAMC439048	Shotgun metagenomic sequencing of human fecal S5
SAMC439047	Shotgun metagenomic sequencing of human fecal S4
SAMC439046	Shotgun metagenomic sequencing of human fecal S3
SAMC439045	Shotgun metagenomic sequencing of human fecal S2
SAMC439044	Shotgun metagenomic sequencing of human fecal S1
GSA (1)	-
CRA004662	Aberrant gut-metabolome-immune network in schizophrenia