项目编号

PRJCA006027

项目标题

Rejuvenation of aging single-cell transcriptomic atlas by heterochronic parabiosis

涉及领域

Model organism

数据类型

Transcriptome or Gene expression

物种名称

Mus musculus

描述信息

This study constructed a single-cell transcriptomic map of multiple aged organs and their modulation by heterochronic parabiosis (HP), observing a continuum of cell state and composition changes across the hematopoietic and immune tissues, and traced it back to hematopoietic stem and progenitor cells (HSPCs). And exposure to the young blood partially reversed the age-associated decline in lymphopoiesis. In addition, even in the skin, a peripheral organ, resident epithelial stem cells were revitalized through systemic effect of HP, albeit a distinctive manner in comparison with HSPCs.

样品范围

Single cell

发布日期

2022-05-16

出版信息

PubMed ID	文章标题	杂志名称	Doi	发表年份
40960906	Mechanical Stretch‐Induced Interlayer Coordination between MMP2 and COL17A1 Exacerbates Regenerative Exhaustion in Skin	Advanced Science	10.1002/advs.202511474	2025
39266768	Aged bone marrow macrophages drive systemic aging and age-related dysfunction via extracellular vesicle-mediated induction of paracrine senescence	Nature Aging	10.1038/s43587-024-00694-0	2024
39264584	The cell rejuvenation atlas: leveraging network biology to identify master regulators of rejuvenation strategies	Aging	10.18632/aging.206105	2024

项目资金来源

机构	项目类型	授权项目ID	授权项目名称
National Key Technologies R&D Program		2020YFA0804000

提交者

Jiaming Li (jiaming_li@foxmail.com)

提交单位

Beijing Institute of Genomics, Chinese Academy of Sciences

提交日期

2021-08-03

项目包含数据信息

资源名称	描述
BioSample (48) show	-
SAMC634262	scRNA-seq of Mus musculus: adult male peripheral blood
SAMC634261	scRNA-seq of Mus musculus: adult male peripheral blood
SAMC634260	scRNA-seq of Mus musculus: adult male peripheral blood
SAMC634259	scRNA-seq of Mus musculus: adult male peripheral blood
SAMC634258	scRNA-seq of Mus musculus: adult male spleen
SAMC634257	scRNA-seq of Mus musculus: adult male spleen
SAMC634256	scRNA-seq of Mus musculus: adult male spleen
SAMC634255	scRNA-seq of Mus musculus: adult male spleen
SAMC634254	scRNA-seq of Mus musculus: adult male Lin(-)Sca-1(+)c-Kit(+) HSC
SAMC634253	scRNA-seq of Mus musculus: adult male Lin(-)Sca-1(+)c-Kit(+) HSC
SAMC634252	scRNA-seq of Mus musculus: adult male Lin(-)Sca-1(+)c-Kit(+) HSC
SAMC634251	scRNA-seq of Mus musculus: adult male Lin(-)Sca-1(+)c-Kit(+) HSC
SAMC634250	scRNA-seq of Mus musculus: adult male bone marrow
SAMC634249	scRNA-seq of Mus musculus: adult male bone marrow
SAMC634248	scRNA-seq of Mus musculus: adult male bone marrow
SAMC634247	scRNA-seq of Mus musculus: adult male bone marrow
SAMC634246	snRNA-seq of Mus musculus: adult male muscle
SAMC634245	snRNA-seq of Mus musculus: adult male muscle
SAMC634244	snRNA-seq of Mus musculus: adult male muscle
SAMC634243	snRNA-seq of Mus musculus: adult male muscle
SAMC634242	snRNA-seq of Mus musculus: adult male liver
SAMC634241	snRNA-seq of Mus musculus: adult male liver
SAMC634240	snRNA-seq of Mus musculus: adult male liver
SAMC634239	snRNA-seq of Mus musculus: adult male liver
SAMC634238	snRNA-seq of Mus musculus: adult male brain
SAMC634237	snRNA-seq of Mus musculus: adult male brain
SAMC634236	snRNA-seq of Mus musculus: adult male brain
SAMC634235	snRNA-seq of Mus musculus: adult male brain
SAMC443674	scRNA-seq of Mus musculus: adult male bone marrow
SAMC438611	scRNA-seq of Mus musculus: adult male Lin(-)Sca-1(+)c-Kit(+) HSC
SAMC438610	scRNA-seq of Mus musculus: adult male Lin(-)Sca-1(+)c-Kit(+) HSC
SAMC438609	scRNA-seq of Mus musculus: adult male Lin(-)Sca-1(+)c-Kit(+) HSC
SAMC438608	scRNA-seq of Mus musculus: adult male Lin(-)Sca-1(+)c-Kit(+) HSC
SAMC438607	scRNA-seq of Mus musculus: adult male spleen
SAMC438606	scRNA-seq of Mus musculus: adult male spleen
SAMC438605	scRNA-seq of Mus musculus: adult male spleen
SAMC438604	scRNA-seq of Mus musculus: adult male spleen
SAMC438603	scRNA-seq of Mus musculus: adult male skin
SAMC438602	scRNA-seq of Mus musculus: adult male skin
SAMC438601	scRNA-seq of Mus musculus: adult male skin
SAMC438600	scRNA-seq of Mus musculus: adult male skin
SAMC438599	scRNA-seq of Mus musculus: adult male peripheral blood
SAMC438598	scRNA-seq of Mus musculus: adult male peripheral blood
SAMC438597	scRNA-seq of Mus musculus: adult male peripheral blood
SAMC438596	scRNA-seq of Mus musculus: adult male peripheral blood
SAMC438595	scRNA-seq of Mus musculus: adult male bone marrow
SAMC438594	scRNA-seq of Mus musculus: adult male bone marrow
SAMC438593	scRNA-seq of Mus musculus: adult male bone marrow
GSA (1)	-
CRA004660	Rejuvenation of aging single-cell transcriptomic atlas by heterochronic parabiosis