Accession PRJCA006027
Title Rejuvenation of aging single-cell transcriptomic atlas by heterochronic parabiosis
Relevance Model organism
Data types Transcriptome or Gene expression
Organisms Mus musculus
Description This study constructed a single-cell transcriptomic map of multiple aged organs and their modulation by heterochronic parabiosis (HP), observing a continuum of cell state and composition changes across the hematopoietic and immune tissues, and traced it back to hematopoietic stem and progenitor cells (HSPCs). And exposure to the young blood partially reversed the age-associated decline in lymphopoiesis. In addition, even in the skin, a peripheral organ, resident epithelial stem cells were revitalized through systemic effect of HP, albeit a distinctive manner in comparison with HSPCs.
Sample scope Single cell
Release date 2022-05-16
Grants
Agency program Grant ID Grant title
No funding support
Submitter Jiaming    Li  (jiaming_li@foxmail.com)
Organization Beijing Institute of Genomics, Chinese Academy of Sciences
Submission date 2021-08-03

Project Data

Resource name Description
BioSample (48)  show -
GSA (1) -
CRA004660 Rejuvenation of aging single-cell transcriptomic atlas by heterochronic parabiosis