Accession

PRJCA006027

Title

Rejuvenation of aging single-cell transcriptomic atlas by heterochronic parabiosis

Relevance

Model organism

Data types

Transcriptome or Gene expression

Organisms

Mus musculus

Description

This study constructed a single-cell transcriptomic map of multiple aged organs and their modulation by heterochronic parabiosis (HP), observing a continuum of cell state and composition changes across the hematopoietic and immune tissues, and traced it back to hematopoietic stem and progenitor cells (HSPCs). And exposure to the young blood partially reversed the age-associated decline in lymphopoiesis. In addition, even in the skin, a peripheral organ, resident epithelial stem cells were revitalized through systemic effect of HP, albeit a distinctive manner in comparison with HSPCs.

Sample scope

Single cell

Release date

2022-05-16

Grants

Agency	program	Grant ID	Grant title
No funding support

Submitter

Jiaming Li (jiaming_li@foxmail.com)

Organization

Beijing Institute of Genomics, Chinese Academy of Sciences

Submission date

2021-08-03

Project Data

Resource name	Description
BioSample (48) show	-
SAMC634262	scRNA-seq of Mus musculus: adult male peripheral blood
SAMC634261	scRNA-seq of Mus musculus: adult male peripheral blood
SAMC634260	scRNA-seq of Mus musculus: adult male peripheral blood
SAMC634259	scRNA-seq of Mus musculus: adult male peripheral blood
SAMC634258	scRNA-seq of Mus musculus: adult male spleen
SAMC634257	scRNA-seq of Mus musculus: adult male spleen
SAMC634256	scRNA-seq of Mus musculus: adult male spleen
SAMC634255	scRNA-seq of Mus musculus: adult male spleen
SAMC634254	scRNA-seq of Mus musculus: adult male Lin(-)Sca-1(+)c-Kit(+) HSC
SAMC634253	scRNA-seq of Mus musculus: adult male Lin(-)Sca-1(+)c-Kit(+) HSC
SAMC634252	scRNA-seq of Mus musculus: adult male Lin(-)Sca-1(+)c-Kit(+) HSC
SAMC634251	scRNA-seq of Mus musculus: adult male Lin(-)Sca-1(+)c-Kit(+) HSC
SAMC634250	scRNA-seq of Mus musculus: adult male bone marrow
SAMC634249	scRNA-seq of Mus musculus: adult male bone marrow
SAMC634248	scRNA-seq of Mus musculus: adult male bone marrow
SAMC634247	scRNA-seq of Mus musculus: adult male bone marrow
SAMC634246	snRNA-seq of Mus musculus: adult male muscle
SAMC634245	snRNA-seq of Mus musculus: adult male muscle
SAMC634244	snRNA-seq of Mus musculus: adult male muscle
SAMC634243	snRNA-seq of Mus musculus: adult male muscle
SAMC634242	snRNA-seq of Mus musculus: adult male liver
SAMC634241	snRNA-seq of Mus musculus: adult male liver
SAMC634240	snRNA-seq of Mus musculus: adult male liver
SAMC634239	snRNA-seq of Mus musculus: adult male liver
SAMC634238	snRNA-seq of Mus musculus: adult male brain
SAMC634237	snRNA-seq of Mus musculus: adult male brain
SAMC634236	snRNA-seq of Mus musculus: adult male brain
SAMC634235	snRNA-seq of Mus musculus: adult male brain
SAMC443674	scRNA-seq of Mus musculus: adult male bone marrow
SAMC438611	scRNA-seq of Mus musculus: adult male Lin(-)Sca-1(+)c-Kit(+) HSC
SAMC438610	scRNA-seq of Mus musculus: adult male Lin(-)Sca-1(+)c-Kit(+) HSC
SAMC438609	scRNA-seq of Mus musculus: adult male Lin(-)Sca-1(+)c-Kit(+) HSC
SAMC438608	scRNA-seq of Mus musculus: adult male Lin(-)Sca-1(+)c-Kit(+) HSC
SAMC438607	scRNA-seq of Mus musculus: adult male spleen
SAMC438606	scRNA-seq of Mus musculus: adult male spleen
SAMC438605	scRNA-seq of Mus musculus: adult male spleen
SAMC438604	scRNA-seq of Mus musculus: adult male spleen
SAMC438603	scRNA-seq of Mus musculus: adult male skin
SAMC438602	scRNA-seq of Mus musculus: adult male skin
SAMC438601	scRNA-seq of Mus musculus: adult male skin
SAMC438600	scRNA-seq of Mus musculus: adult male skin
SAMC438599	scRNA-seq of Mus musculus: adult male peripheral blood
SAMC438598	scRNA-seq of Mus musculus: adult male peripheral blood
SAMC438597	scRNA-seq of Mus musculus: adult male peripheral blood
SAMC438596	scRNA-seq of Mus musculus: adult male peripheral blood
SAMC438595	scRNA-seq of Mus musculus: adult male bone marrow
SAMC438594	scRNA-seq of Mus musculus: adult male bone marrow
SAMC438593	scRNA-seq of Mus musculus: adult male bone marrow
GSA (1)	-
CRA004660	Rejuvenation of aging single-cell transcriptomic atlas by heterochronic parabiosis