| Accession |
PRJCA006139 |
| Title |
scRNA-seq of rat testis |
| Relevance |
Model organism |
| Data types |
Transcriptome or Gene expression
Raw sequence reads
Single cell sequencing
|
| Organisms |
Rattus norvegicus
Rattus
|
| Description |
It is well-known that spermatogenesis is regulated by male hormone testosterone. But the mechanism involved is not known completely. Here we present a single cell-RNA sequencing experiment that analyzed the testicular cell compositional changes before and after Leydig cell elimination by Ethylene Dimethane Suiphonate (EDS) . The experiment contains 4 samples that covers a whole testosterone withdrawal and restoration cycle. The dataset is useful for studying how spermatogenesis is regulated by testosterone, which could benefit the male reproductive field greatly. |
| Sample scope |
Single cell |
| Release date |
2022-02-13 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 35338159
|
Single-cell RNA sequencing of adult rat testes after Leydig cell elimination and restoration
|
Scientific Data
|
10.1038/s41597-022-01225-5
|
2022
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
Major Research Plan
|
91949123
|
Study of molecular mechanism by which miR-299a-5p/NF-kB regulatory loop promotes testicular Leydig cell aging process
|
|
|
| Submitter |
Haolin
Chen (haolinchen8@163.com)
|
| Organization |
The Second Affiliated Hospital of Wenzhou Medical University |
| Submission date |
2021-08-11 |
