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项目编号 PRJCA006267
项目标题 comparation of immune microenvironment between brain tumors and primary lung cancer tumors
涉及领域 Medical
数据类型 Transcriptome or Gene expression
物种名称 Cancer
描述信息 Forty-three Chinese patients with NSCLC who had brain metastasis at presentation or during the course of their disease were admitted to the Sun Yat-Sen University Cancer Center from 2000 to 2019. RNA sequencing (RNA-seq) of eighty-six formalin-fixed, paraffin embedded (FFPE) samples from primary lung tumors and paired brain metastases of 43 patients was conducted to comprehensively analyze the tumor immune microenvironment.
样品范围 Multiisolate
发布日期 2021-12-31
出版信息
PubMed ID 文章标题 杂志名称 Doi 发表年份
35402080 Immune suppressive microenvironment in brain metastatic non-small cell lung cancer: comprehensive immune microenvironment profiling of brain metastases versus paired primary lung tumors (GASTO 1060) OncoImmunology  10.1080/2162402X.2022.2059874 2022
38744278 Targeting the HSP47-collagen axis inhibits brain metastasis by reversing M2 microglial polarization and restoring anti-tumor immunity Cell Reports Medicine 10.1016/j.xcrm.2024.101533 2024
39593098 An immune scoring system predicts prognosis and immune characteristics in lung adenocarcinoma brain metastases by RNA sequencing Acta Neuropathologica Communications 10.1186/s40478-024-01895-9 2024
41376899 Single-cell and spatial transcriptome landscapes reveal the spatial immune defense pattern shared by primary and brain metastatic lung adenocarcinoma Peer Review File Journal of Thoracic Disease 10.21037/jtd-2025-1224 2025
项目资金来源
机构 项目类型 授权项目ID 授权项目名称
National Natural Science Foundation of China (NSFC) 82072559
提交者 Likun Chen (chenlk@sysucc.org.cn)
提交单位 Sun Yat-sen University Cancer Center
提交日期 2021-08-23

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