| 项目编号 |
PRJCA006287 |
| 项目标题 |
Comparative analyses of diverse human long-read assemblies inform genomic divergence between African and non-African |
| 涉及领域 |
Evolution |
| 数据类型 |
Genome sequencing and assembly
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Given our increased awareness of genomic diversity, more high-quality reference genomes are necessary for understanding human evolution and genome complexity. Here, we produced 35 high-quality genomes of diverse humans from across the world assembled by more than 50x long reads complemented with short-read sequencing. 283.8 Mb of novel sequences were not present in the reference genome, particularly in Africans, who displayed larger genome size and more novel sequences. The assemblies facilitate investigations on evolutionary dynamics of the largest gene family, i.e., olfactory receptors across diverse human populations. Africans and non-Africans exhibited differentiation of olfactory receptor patterns, while Asians displayed higher olfactory sensitivity than Africans. Comparative population genomics identified structural variants with population differentiation between African and non-African populations, possibly causing different phenotypes and incidences of certain diseases. Finally, by mapping to these de novo genomes, we categorized insertions introgressed from archaic hominins. This study presents comprehensive genome data and diverse assemblies, which should help improve our understanding of human evolution and could be applied in future genetic studies. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2023-05-25 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 38671502
|
NextDenovo: an efficient error correction and accurate assembly tool for noisy long reads
|
Genome Biology
|
10.1186/s13059-024-03252-4
|
2024
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Chinese Academy of Sciences (CAS)
|
Strategic Priority Research Program of Chinese Academy of Sciences (CAS)
|
XDPB17
|
|
|
|
| 提交者 |
Dong-Dong
Wu (wudongdong@mail.kiz.ac.cn)
|
| 提交单位 |
Kunming Institute of Zoology, Chinese Academy of Sciences |
| 提交日期 |
2021-08-24 |
