| Accession | PRJCA006448 | ||||||||||||||||||||
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| Title | Patient-derived 2D&3D Model Deciphering Multifunctional Heterogeneity at the Single-cell Level | ||||||||||||||||||||
| Relevance | Medical | ||||||||||||||||||||
| Data types |
Transcriptome or Gene expression
Raw sequence reads Single cell sequencing |
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| Organisms | Homo sapiens | ||||||||||||||||||||
| Description | Intra-tumoral functional heterogeneity is highly associated with poor prognosis and therapeutic failure, but remains largely unexplored due to model limitations. Here we established a 2D&3D model of cancer cells and air-liquid interface organoids derived from colorectal cancer patients, and generated multiple single-cell-derived clones from individual tumors. This innovative 2D&3D model faithfully recapitulate the histological, genomic, and transcriptomic characteristics and heterogeneity of their parental tumors. | ||||||||||||||||||||
| Sample scope | Multiisolate | ||||||||||||||||||||
| Release date | 2021-09-06 | ||||||||||||||||||||
| Grants |
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| Submitter | Xia Wang (xiawang@mail.tsinghua.edu.cn) | ||||||||||||||||||||
| Organization | Tsinghua University | ||||||||||||||||||||
| Submission date | 2021-09-06 |
| Resource name | Description |
|---|---|
| BioSample (113) show | - |