| 项目编号 | PRJCA006448 | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 项目标题 | Patient-derived 2D&3D Model Deciphering Multifunctional Heterogeneity at the Single-cell Level | ||||||||||||||||||||
| 涉及领域 | Medical | ||||||||||||||||||||
| 数据类型 |
Transcriptome or Gene expression
Raw sequence reads Single cell sequencing |
||||||||||||||||||||
| 物种名称 | Homo sapiens | ||||||||||||||||||||
| 描述信息 | Intra-tumoral functional heterogeneity is highly associated with poor prognosis and therapeutic failure, but remains largely unexplored due to model limitations. Here we established a 2D&3D model of cancer cells and air-liquid interface organoids derived from colorectal cancer patients, and generated multiple single-cell-derived clones from individual tumors. This innovative 2D&3D model faithfully recapitulate the histological, genomic, and transcriptomic characteristics and heterogeneity of their parental tumors. | ||||||||||||||||||||
| 样品范围 | Multiisolate | ||||||||||||||||||||
| 发布日期 | 2021-09-06 | ||||||||||||||||||||
| 项目资金来源 |
|
||||||||||||||||||||
| 提交者 | Xia Wang (xiawang@mail.tsinghua.edu.cn) | ||||||||||||||||||||
| 提交单位 | Tsinghua University | ||||||||||||||||||||
| 提交日期 | 2021-09-06 |
| 资源名称 | 描述 |
|---|---|
| BioSample (113) show | - |