| 项目编号 |
PRJCA006656 |
| 项目标题 |
Periodontal microbiota-induced IL-17+ γδ T promote OSCC development |
| 涉及领域 |
Medical |
| 数据类型 |
Metagenome
Raw sequence reads
Genome sequencing
|
| 物种名称 |
Microbiota
|
| 描述信息 |
OSCC is related to periodontitis, and the oral cavity is colonized by a vast number of commensal microbiota. However, changes in the oral microbial community in OSCC with periodontitis have not yet to be defined. Mechanistically, the role of the periodontitis microbiota in carcinogenesis is still lacking. Confirmed by our data, periodontitis microbiota or antibiotic treatment promoted the development of OSCC, accompanied by the oral altered bacterial community. Periodontitis microbiota induce the expansion of M2-TAM and the activation of IL-17+ γδ T cells associated with OSCC development, and then the IL-17+ γδ T cells promote tumor cell proliferation by the IL-17/STAT3 pathway. Our data suggested an insight into the pathogenesis of OSCC with periodontitis by outlining the tumor-associated immune response shaped by periodontitis microbiota and hope to provide new research and intervention targets for OSCC with periodontitis. |
| 样品范围 |
Synthetic |
| 发布日期 |
2021-09-22 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 36000726
|
Oral Microbiota from Periodontitis Promote Oral Squamous Cell Carcinoma Development via γδ T Cell Activation
|
mSystems
|
10.1128/msystems.00469-22
|
2022
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
81771085
|
|
| Key Projects of Sichuan Provincial Department of Science and Technology
|
|
2020YFSY0008
|
|
|
|
| 提交者 |
Wei
Wei (hxkqww@163.com)
|
| 提交单位 |
Sichuan University |
| 提交日期 |
2021-09-22 |
