| Accession |
PRJCA006765 |
| Title |
Epigenetic Impact of Chronic Inflammation On Colon Mucosa Cells |
| Relevance |
Medical |
| Data types |
Epigenomics
|
| Organisms |
Mus
|
| Description |
To investigate how DNA methylation alterations contribute to inflammation-associated carcinogenesis, chronic colitis mouse model was established by dextran sodium sulfate (DSS) treated and then colon mucosa were separated for Bisulfite genomic sequencing.Differentially methylated regions (DMR) assay indicated methylation in both the upstream, downstream and genebody regions was significant different. Subsequently, Functional analysis showed that differentially methylated genes in chronic inflammation are enriched in the signal pathways related to carcinogenesis. The results suggested that a part of genes related to cancer development appear epigenetical alteration by chronic inflammation. |
| Sample scope |
Monoisolate |
| Release date |
2021-10-11 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 34764977
|
Genetic and Epigenetic Impact of Chronic Inflammation on Colon Mucosa Cells
|
Frontiers in Genetics
|
10.3389/fgene.2021.722835
|
2021
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Special fund of Foshan Summit plan
|
|
2019A006
|
|
| Natural Science Foundation of Guangdong Province
|
|
2020A1515110432
|
|
|
|
| Submitter |
Jia
He (hejia021@126.com)
|
| Organization |
The First People's Hospital of Foshan |
| Submission date |
2021-09-30 |
