| Accession |
PRJCA006795 |
| Title |
Nsun2 coupling with RoRγt regulates Th17 cell homeostasis and promotes colitis |
| Relevance |
Model organism |
| Data types |
Epigenomics
Transcriptome or Gene expression
|
| Organisms |
Mus musculus
|
| Description |
This project demonstrates a T cell-intrinsic role mediated by Nsun2 in promoting autoimmunity, in which the pathogenicity of Th17 cells is sustained by coupling of Nsun2 and RoRγt to stabilize Il17a and Il17f, thereby suggesting a potential therapeutic target for clinical autoimmune disease. |
| Sample scope |
Monoisolate |
| Release date |
2023-04-21 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 36792629
|
Nsun2 coupling with RoRγt shapes the fate of Th17 cells and promotes colitis
|
Nature Communications
|
10.1038/s41467-023-36595-w
|
2023
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
Excellent Young Scientists Fund
|
31625016
|
Gene expression regulation and epigenetics
|
| Chinese Academy of Sciences (CAS)
|
Strategic Priority Research Program of Chinese Academy of Sciences (CAS)
|
XDA16010501
|
Innovative technologies for epigenetic sequencing and analysis of organ regeneration
|
|
|
| Submitter |
Yun-Gui
Yang (ygyang_data@big.ac.cn)
|
| Organization |
Beijing Institute of Genomics, Chinese Academy of Sciences |
| Submission date |
2021-10-06 |
